6VDB
SETD2 in complex with a H3-variant super-substrate peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETD2 | polymer | 295 | 34098.8 | 1 | UniProt (Q9BYW2) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP |
| 2 | B (H) | ALA-PRO-ARG-PHE-GLY-GLY-VAL-MET-ARG-PRO-ASN-ARG | polymer | 14 | 1681.0 | 1 | synthetic construct | ||
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | AA, D, E, F, G... (H, A) | UNKNOWN LIGAND | non-polymer | 65.4 | 20 | Chemie (UNX) | |||
| 5 | W, X, Y (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | Z (H) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 7 | BA, CA (A, H) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 1433 - 1711 (UniProt: Q9BYW2)
| PDB | External Database | Details |
|---|---|---|
| Met 1417 | - | initiating methionine |
| His 1418 | - | expression tag |
| His 1419 | - | expression tag |
| His 1420 | - | expression tag |
| His 1421 | - | expression tag |
| His 1422 | - | expression tag |
| His 1423 | - | expression tag |
| Ser 1424 | - | expression tag |
| Ser 1425 | - | expression tag |
| Gly 1426 | - | expression tag |
| Arg 1427 | - | expression tag |
| Glu 1428 | - | expression tag |
| Asn 1429 | - | expression tag |
| Leu 1430 | - | expression tag |
| Tyr 1431 | - | expression tag |
| Phe 1432 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35779.8 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1946.9 | |
| All* | Total formula weight | 37726.7 |
