6VDB
SETD2 in complex with a H3-variant super-substrate peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETD2 | polymer | 295 | 34098.8 | 1 | UniProt (Q9BYW2) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP |
| 2 | B (H) | ALA-PRO-ARG-PHE-GLY-GLY-VAL-MET-ARG-PRO-ASN-ARG | polymer | 14 | 1681.0 | 1 | synthetic construct | ||
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | AA, D, E, F, G... (H, A) | UNKNOWN LIGAND | non-polymer | 65.4 | 20 | Chemie (UNX) | |||
| 5 | W, X, Y (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | Z (H) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) PubChem (9322) | |||
| 7 | BA, CA (A, H) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 1433 - 1711 (UniProt: Q9BYW2)
| PDB | External Database | Details |
|---|---|---|
| Met 1417 | - | initiating methionine |
| His 1418 | - | expression tag |
| His 1419 | - | expression tag |
| His 1420 | - | expression tag |
| His 1421 | - | expression tag |
| His 1422 | - | expression tag |
| His 1423 | - | expression tag |
| Ser 1424 | - | expression tag |
| Ser 1425 | - | expression tag |
| Gly 1426 | - | expression tag |
| Arg 1427 | - | expression tag |
| Glu 1428 | - | expression tag |
| Asn 1429 | - | expression tag |
| Leu 1430 | - | expression tag |
| Tyr 1431 | - | expression tag |
| Phe 1432 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35779.8 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1946.9 | |
| All* | Total formula weight | 37726.7 |
