6VDB

SETD2 in complex with a H3-variant super-substrate peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0046975	molecular_function	histone H3K36 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SAH A 1901

Chain	Residue
A	LYS1560
A	HIS1629
A	TYR1666
A	GLN1676
A	LYS1677
A	CYS1678
A	PHE1679
A	LEU1689
A	GLY1561
A	TRP1562
A	HIS1603
A	TYR1604
A	TYR1605
A	ARG1625
A	PHE1626
A	ASN1628

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1921

Chain	Residue
A	CYS1499
A	CYS1501
A	CYS1516
A	CYS1520

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1922

Chain	Residue
A	CYS1516
A	CYS1529
A	CYS1533
A	CYS1539

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1923

Chain	Residue
A	CYS1631
A	CYS1678
A	CYS1680
A	CYS1685

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SCN H 101

Chain	Residue
A	GLN1638
A	LYS1639
H	PRO38
H	ASN39
H	ARG40

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	117
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V21","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---