6V6Q
Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Fibroblast growth factor receptor 2 | polymer | 411 | 46466.1 | 4 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | E, G, I, K (A, B, C, D) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 4 | Chemie (ACP) | |||
| 3 | F, H, J, L (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 413 - 821 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Gly 411 | - | expression tag |
| Ser 412 | - | expression tag |
| Phe 466 | Tyr 466 | engineered mutation |
| Phe 561 | Tyr 561 | engineered mutation |
| Phe 566 | Tyr 566 | engineered mutation |
| Phe 575 | Tyr 575 | engineered mutation |
| Phe 586 | Tyr 586 | engineered mutation |
| Phe 588 | Tyr 588 | engineered mutation |
| Phe 608 | Tyr 608 | engineered mutation |
| Phe 616 | Tyr 616 | engineered mutation |
| Phe 657 | Tyr 657 | engineered mutation |
| Phe 733 | Tyr 733 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 185864.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2118.1 | |
| All* | Total formula weight | 187982.5 |
