6V6Q

Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ACP A 901

Chain	Residue
A	LEU487
A	LEU633
A	ASP644
A	MG902
A	HOH1001
A	HOH1012
A	HOH1016
A	HOH1017
A	GLY488
A	GLY490
A	VAL495
A	ALA515
A	VAL564
A	GLU565
A	PHE566
A	ALA567

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 902

Chain	Residue
A	ASN631
A	ASP644
A	ACP901
A	HOH1001
A	HOH1016

---

site_id	AC3
Number of Residues	18
Details	binding site for residue ACP B 901

Chain	Residue
B	LEU487
B	GLY488
B	GLY490
B	ALA515
B	VAL564
B	GLU565
B	PHE566
B	ALA567
B	ASN571
B	LEU633
B	ASP644
B	MG902
B	HOH1002
B	HOH1015
B	HOH1017
B	HOH1023
B	HOH1024
B	HOH1054

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG B 902

Chain	Residue
B	ASN631
B	ASP644
B	ACP901
B	HOH1023

---

site_id	AC5
Number of Residues	12
Details	binding site for residue ACP C 901

Chain	Residue
C	LEU487
C	GLY490
C	ALA515
C	VAL564
C	GLU565
C	PHE566
C	ALA567
C	LEU633
C	ASP644
C	MG902
C	HOH1001
C	HOH1002

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 902

Chain	Residue
C	ASN631
C	ASP644
C	ACP901

---

site_id	AC7
Number of Residues	13
Details	binding site for residue ACP D 901

Chain	Residue
D	LEU487
D	ALA515
D	LYS517
D	VAL564
D	GLU565
D	PHE566
D	ALA567
D	ASN571
D	LEU633
D	ASP644
D	MG902
D	HOH1002
D	HOH1003

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG D 902

Chain	Residue
D	ASP644
D	ACP901
D	HOH1002
D	HOH1003

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVmAeavgidkdkpkeavt...VAVK

Chain	Residue	Details
A	LEU487-LYS517

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS622-VAL634

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208

Chain	Residue	Details
A	ASP626
B	ASP626
C	ASP626
D	ASP626

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208

Chain	Residue	Details
A	LEU487
C	LYS517
C	GLU565
C	ASN571
D	LEU487
D	LYS517
D	GLU565
D	ASN571
A	LYS517
A	GLU565
A	ASN571
B	LEU487
B	LYS517
B	GLU565
B	ASN571
C	LEU487

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646

Chain	Residue	Details
A	PHE466
A	PHE588
B	PHE466
B	PHE588
C	PHE466
C	PHE588
D	PHE466
D	PHE588

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646

Chain	Residue	Details
A	PHE586
D	PHE586
D	PTR656
D	PHE657
A	PTR656
A	PHE657
B	PHE586
B	PTR656
B	PHE657
C	PHE586
C	PTR656
C	PHE657

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:19060208

Chain	Residue	Details
A	TYR769
B	TYR769
C	TYR769
D	TYR769

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER780
B	SER780
C	SER780
D	SER780

---