6V16
Crystal structure of the bromodomain of human BRD7 bound to TP472
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain-containing protein 7 | polymer | 123 | 14394.6 | 2 | UniProt (Q9NPI1) Pfam (PF00439) | Homo sapiens (Human) | 75 kDa bromodomain protein,Protein CELTIX-1 |
| 2 | C, E (A, B) | 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide | non-polymer | 333.4 | 2 | Chemie (QMG) | |||
| 3 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | F (B) | HEXANE-1,6-DIOL | non-polymer | 118.2 | 1 | Chemie (HEZ) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 250 (UniProt: Q9NPI1)
| PDB | External Database | Details |
|---|---|---|
| Glu 128 | - | expression tag |
| Ser 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28789.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 939.1 | |
| All* | Total formula weight | 29728.4 |
