6V0Q
Crystal structure of the bromodomain of human BRD7 bound to TG003
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bromodomain-containing protein 7 | polymer | 123 | 14394.6 | 4 | UniProt (Q9NPI1) Pfam (PF00439) | Homo sapiens (Human) | 75 kDa bromodomain protein,Protein CELTIX-1 |
| 2 | E, F, L, N (A, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | G (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | I, K, M, O (A, B, C, D) | (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | non-polymer | 249.3 | 4 | Chemie (EAE) | |||
| 6 | J (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 487 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 250 (UniProt: Q9NPI1)
| PDB | External Database | Details |
|---|---|---|
| Glu 128 | - | expression tag |
| Ser 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57578.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1468.1 | |
| All* | Total formula weight | 59046.7 |
