6V0Q

Crystal structure of the bromodomain of human BRD7 bound to TG003

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 301

Chain	Residue
A	PHE163
A	HOH431

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site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	THR215
A	ILE216
A	TYR217
A	HOH403
A	HOH430
A	HOH497

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 A 303

Chain	Residue
A	HOH401
C	LYS150
C	SER227
C	LYS230
A	LYS201

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 304

Chain	Residue
A	GLN234

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EAE A 305

Chain	Residue
A	PHE155
A	PHE156
A	ILE164
A	ASN211
A	TYR217
A	HOH419
B	PHE163

---

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL A 306

Chain	Residue
A	LYS150
C	LYS197
C	LYS201
C	GLN234

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EAE B 301

Chain	Residue
A	PHE163
B	PHE155
B	PHE156
B	VAL160
B	ILE164
B	ASN211
B	TYR217
B	HOH416

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO C 301

Chain	Residue
A	HIS226
A	LYS230
A	HOH411
C	HOH436

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EAE C 302

Chain	Residue
C	PHE155
C	PHE156
C	ILE164
C	ASN211
C	TYR217
C	HOH407
D	PHE163

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO D 301

Chain	Residue
D	LYS184
D	ASP189
D	GLU195
D	HOH422

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EAE D 302

Chain	Residue
D	PHE155
D	PHE156
D	ILE164
D	ASN211
D	TYR217
D	HOH401

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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