6URH
Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C | HCV envelope glycoprotein E2 | polymer | 264 | 29116.7 | 1 | UniProt (A0A2P0NE21) Pfam (PF01560) UniProt (by SIFTS) (A0A2P0NE26) In PDB | Hepacivirus C | |
2 | H | AR3X Heavy Chain | polymer | 254 | 27450.8 | 1 | Homo sapiens | ||
3 | L | AR3X Light Chain | polymer | 214 | 23175.6 | 1 | Homo sapiens | ||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | B | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G12615HA) | |||
6 | D | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
7 | E | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
8 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
9 | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
C: 384 - 645 (UniProt: A0A2P0NE21)
PDB | External Database | Details |
---|---|---|
Ile 646 | - | expression tag |
Gly 647 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 79743.1 | |
Branched | Number of molecules | 4 |
Total formula weight | 3156.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 83121.2 |