6URH

Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	HCV envelope glycoprotein E2	polymer	264	29116.7	1	UniProt (A0A2P0NE21) Pfam (PF01560) UniProt (by SIFTS) (A0A2P0NE26) In PDB	Hepacivirus C
2	H	AR3X Heavy Chain	polymer	254	27450.8	1		Homo sapiens
3	L	AR3X Light Chain	polymer	214	23175.6	1		Homo sapiens
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	B	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G12615HA)
6	D	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)
7	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G55220VL)
8	C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9		water	water		18.0	202	Chemie (HOH)

Sequence modifications

C: 384 - 645 (UniProt: A0A2P0NE21)

PDB	External Database	Details
Ile 646	-	expression tag
Gly 647	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	79743.1
Branched	Number of molecules	4
	Total formula weight	3156.9
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	83121.2

*Water molecules are not included.