6UNP
Crystal structure of the kinase domain of BMPR2-D485G
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bone morphogenetic protein receptor type-2 | polymer | 363 | 41721.8 | 2 | UniProt (Q13873) Pfam (PF00069) | Homo sapiens (Human) | BMPR-2,Bone morphogenetic protein receptor type II,BMPR-II |
| 2 | C, D, P (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 3 | AA, E, F, G, H... (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 18 | Chemie (MG) | |||
| 4 | BA, CA, L, M, N (B, A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | DA, EA, O (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | FA, GA (A, B) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 188 - 529 (UniProt: Q13873)
| PDB | External Database | Details |
|---|---|---|
| Met 167 | - | initiating methionine |
| Gly 168 | - | expression tag |
| Ser 169 | - | expression tag |
| Ser 170 | - | expression tag |
| His 171 | - | expression tag |
| His 172 | - | expression tag |
| His 173 | - | expression tag |
| His 174 | - | expression tag |
| His 175 | - | expression tag |
| His 176 | - | expression tag |
| Ser 177 | - | expression tag |
| Ser 178 | - | expression tag |
| Gly 179 | - | expression tag |
| Glu 180 | - | expression tag |
| Asn 181 | - | expression tag |
| Leu 182 | - | expression tag |
| Tyr 183 | - | expression tag |
| Phe 184 | - | expression tag |
| Gln 185 | - | expression tag |
| Gly 186 | - | expression tag |
| His 187 | - | expression tag |
| Gly 485 | Asp 485 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83443.7 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2385.6 | |
| All* | Total formula weight | 85829.3 |
