6UNP

Crystal structure of the kinase domain of BMPR2-D485G

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bone morphogenetic protein receptor type-2	polymer	363	41721.8	2	UniProt (Q13873) Pfam (PF00069) In PDB	Homo sapiens (Human)	BMPR-2,Bone morphogenetic protein receptor type II,BMPR-II
2	A, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	3	Chemie (ADP)
3	B, A	MAGNESIUM ION	non-polymer		24.3	18	Chemie (MG)
4	B, A	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
5	B, A	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
6		water	water		18.0	94	Chemie (HOH)

Sequence modifications

A, B: 188 - 529 (UniProt: Q13873)

PDB	External Database	Details
Met 167	-	initiating methionine
Gly 168	-	expression tag
Ser 169	-	expression tag
Ser 170	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
Ser 177	-	expression tag
Ser 178	-	expression tag
Gly 179	-	expression tag
Glu 180	-	expression tag
Asn 181	-	expression tag
Leu 182	-	expression tag
Tyr 183	-	expression tag
Phe 184	-	expression tag
Gln 185	-	expression tag
Gly 186	-	expression tag
His 187	-	expression tag
Gly 485	Asp 485	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83443.7
Non-Polymers*	Number of molecules	29
	Total formula weight	2385.6
All*	Total formula weight	85829.3

*Water molecules are not included.