6UNP
Crystal structure of the kinase domain of BMPR2-D485G
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue ADP A 601 |
| Chain | Residue |
| A | ILE209 |
| A | MET279 |
| A | GLU280 |
| A | TYR282 |
| A | ARG337 |
| A | ASN338 |
| A | LEU340 |
| A | ASP351 |
| A | MG603 |
| A | MG609 |
| A | HOH711 |
| A | GLY210 |
| A | HOH715 |
| A | HOH717 |
| A | HOH723 |
| A | HOH726 |
| A | HOH732 |
| A | GLY212 |
| A | ARG213 |
| A | TYR214 |
| A | GLY215 |
| A | VAL217 |
| A | ALA228 |
| A | LYS230 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue ADP A 602 |
| Chain | Residue |
| A | GLY360 |
| A | ASN361 |
| A | ARG362 |
| A | LEU363 |
| B | PRO250 |
| B | GLU318 |
| B | ASP323 |
| B | HIS324 |
| B | TYR325 |
| B | HOH727 |
| B | HOH751 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | ASN338 |
| A | ASP351 |
| A | ADP601 |
| A | HOH717 |
| A | HOH726 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | TRP298 |
| A | CYS302 |
| A | LEU504 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 605 |
| Chain | Residue |
| A | ARG357 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 606 |
| Chain | Residue |
| A | ARG381 |
| A | MET383 |
| A | TYR407 |
| A | PHE436 |
| A | MET449 |
| A | VAL453 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 607 |
| Chain | Residue |
| A | CAS496 |
| A | GLU499 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 608 |
| Chain | Residue |
| A | ALA235 |
| A | ASN236 |
| A | ARG237 |
| A | GLN238 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 609 |
| Chain | Residue |
| A | GLY212 |
| A | ARG213 |
| A | ADP601 |
| A | SO4611 |
| A | HOH726 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 610 |
| Chain | Residue |
| A | ARG337 |
| A | ARG381 |
| A | ASN442 |
| A | HIS443 |
| A | HOH722 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 611 |
| Chain | Residue |
| A | GLY212 |
| A | ARG213 |
| A | ARG337 |
| A | MG609 |
| A | HOH705 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 612 |
| Chain | Residue |
| A | ARG362 |
| B | ASN245 |
| B | ARG357 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | LYS219 |
| B | LYS219 |
| site_id | AD5 |
| Number of Residues | 26 |
| Details | binding site for residue ADP B 601 |
| Chain | Residue |
| B | HOH734 |
| B | HOH736 |
| B | HOH739 |
| B | ILE209 |
| B | GLY210 |
| B | GLY212 |
| B | ARG213 |
| B | TYR214 |
| B | GLY215 |
| B | VAL217 |
| B | ALA228 |
| B | LYS230 |
| B | MET279 |
| B | GLU280 |
| B | TYR282 |
| B | SER286 |
| B | ARG337 |
| B | ASN338 |
| B | LEU340 |
| B | ASP351 |
| B | MG602 |
| B | HOH708 |
| B | HOH717 |
| B | HOH718 |
| B | HOH726 |
| B | HOH732 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 602 |
| Chain | Residue |
| B | ASN338 |
| B | ASP351 |
| B | ADP601 |
| B | HOH717 |
| B | HOH718 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 603 |
| Chain | Residue |
| B | PRO226 |
| B | GLU280 |
| B | TYR281 |
| B | HOH731 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 604 |
| Chain | Residue |
| B | LYS244 |
| B | ARG248 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 605 |
| Chain | Residue |
| B | GLU243 |
| B | TYR247 |
| B | ASP351 |
| B | HOH726 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 606 |
| Chain | Residue |
| B | TYR290 |
| B | HOH728 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 607 |
| Chain | Residue |
| B | LEU291 |
| B | HIS294 |
| B | THR295 |
| B | SER296 |
| B | MG609 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 608 |
| Chain | Residue |
| B | HIS316 |
| B | THR493 |
| B | ALA494 |
| B | HOH756 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 609 |
| Chain | Residue |
| B | SER301 |
| B | ILE416 |
| B | ARG419 |
| B | MG607 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 610 |
| Chain | Residue |
| B | GLU318 |
| B | GLU398 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 611 |
| Chain | Residue |
| B | HIS316 |
| B | LYS402 |
| B | HOH743 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 612 |
| Chain | Residue |
| A | HOH702 |
| B | ILE209 |
| B | TYR281 |
| B | HOH713 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 613 |
| Chain | Residue |
| A | ARG211 |
| B | HIS294 |
| B | THR295 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 614 |
| Chain | Residue |
| B | ARG337 |
| B | ARG381 |
| B | HIS443 |
| B | PRO444 |
| B | HOH707 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 615 |
| Chain | Residue |
| B | ARG211 |
| B | GLY212 |
| B | ARG213 |
| B | GLY215 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 616 |
| Chain | Residue |
| B | ARG337 |
| B | HOH722 |
| B | HOH736 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGRYGAVYkGslderp............VAVK |
| Chain | Residue | Details |
| A | ILE209-LYS230 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of the BMPR2 kinase domain.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
