6U8W
Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | DNA (cytosine-5)-methyltransferase 3B | polymer | 291 | 33128.3 | 2 | UniProt (Q9UBC3) Pfam (PF00145) | Homo sapiens (Human) | Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB |
| 2 | B, C (B, C) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24163.7 | 2 | UniProt (Q9UJW3) | Homo sapiens (Human) | |
| 3 | E, F (E, F) | CpGpT DNA (25-MER) | polymer | 25 | 7699.0 | 2 | Homo sapiens | ||
| 4 | G, I (A, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 5 | H, J (A, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | K, L, M (A, D, F) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, D: 563 - 853 (UniProt: Q9UBC3)
| PDB | External Database | Details |
|---|---|---|
| Ala 777 | Lys 777 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 129982.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 817.4 | |
| All* | Total formula weight | 130799.4 |
