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6U8W

Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, D)
DNA (cytosine-5)-methyltransferase 3Bpolymer29133128.32UniProt (Q9UBC3)
Pfam (PF00145)
Homo sapiens (Human)Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB
2B, C
(B, C)
DNA (cytosine-5)-methyltransferase 3-likepolymer20924163.72UniProt (Q9UJW3)Homo sapiens (Human)
3E, F
(E, F)
CpGpT DNA (25-MER)polymer257699.02Homo sapiens
4G, I
(A, D)
S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.42Chemie (SAH)
5H, J
(A, D)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
6K, L, M
(A, D, F)
waterwater18.011Chemie (HOH)
Sequence modifications
A, D: 563 - 853 (UniProt: Q9UBC3)
PDBExternal DatabaseDetails
Ala 777Lys 777engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight129982.0
Non-Polymers*Number of molecules4
Total formula weight817.4
All*Total formula weight130799.4
*Water molecules are not included.

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PDB entries from 2025-07-23

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