6U6I

NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, A, B, D)	Glutamate receptor 2	polymer	889	99530.4	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	E, H (E, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	F, G (F, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	I (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

C, A, B, D: -14 - 853 (UniProt: P19491)

PDB	External Database	Details
Arg 592	Gln 607	conflict
Asp 854	-	expression tag
Tyr 855	-	expression tag
Lys 856	-	expression tag
Asp 857	-	expression tag
Asp 858	-	expression tag
Asp 859	-	expression tag
Asp 860	-	expression tag
Lys 861	-	expression tag
Glu 862	-	expression tag
Gly 863	-	expression tag
Tyr 864	-	expression tag
Asn 865	-	expression tag
Val 866	-	expression tag
Tyr 867	-	expression tag
Gly 868	-	expression tag
Ile 869	-	expression tag
Glu 870	-	expression tag
Ser 871	-	expression tag
Val 872	-	expression tag
Lys 873	-	expression tag
Ile 874	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	398121.6
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	400364.7

*Water molecules are not included.