6U6I

NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2780
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
C	VAL7-ALA528
C	THR623-ASN797
A	VAL7-ALA528
A	THR623-ASN797
B	VAL7-ALA528
B	THR623-ASN797
D	VAL7-ALA528
D	THR623-ASN797

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	TRANSMEM: Helical

Chain	Residue	Details
C	TYR529-VAL549
C	LEU602-TYR622
A	TYR529-VAL549
A	LEU602-TYR622
B	TYR529-VAL549
B	LEU602-TYR622
D	TYR529-VAL549
D	LEU602-TYR622

---

site_id	SWS_FT_FI3
Number of Residues	124
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
C	SER550-GLU576
C	ASP596-SER601
A	SER550-GLU576
A	ASP596-SER601
B	SER550-GLU576
B	ASP596-SER601
D	SER550-GLU576
D	ASP596-SER601

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	INTRAMEM: Helical; Pore-forming

Chain	Residue	Details
C	PHE577-ARG592
A	PHE577-ARG592
B	PHE577-ARG592
D	PHE577-ARG592

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	INTRAMEM:

Chain	Residue	Details
C	GLN593-CYS595
A	GLN593-CYS595
B	GLN593-CYS595
D	GLN593-CYS595

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=M4

Chain	Residue	Details
C	VAL798-ILE818
A	VAL798-ILE818
B	VAL798-ILE818
D	VAL798-ILE818

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
C	PRO484
A	SER660
A	THR661
A	GLU711
B	PRO484
B	THR486
B	ARG491
B	SER660
B	THR661
B	GLU711
D	PRO484
C	THR486
D	THR486
D	ARG491
D	SER660
D	THR661
D	GLU711
C	ARG491
C	SER660
C	THR661
C	GLU711
A	PRO484
A	THR486
A	ARG491

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
C	ARG459
D	ARG459
D	ARG666
D	LYS758
C	ARG666
C	LYS758
A	ARG459
A	ARG666
A	LYS758
B	ARG459
B	ARG666
B	LYS758

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
C	ILE639
A	ILE639
B	ILE639
D	ILE639

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
C	SER668
A	SER668
B	SER668
D	SER668

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
C	SER702
A	SER702
B	SER702
D	SER702

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819

Chain	Residue	Details
C	SER845
C	SER848
A	SER845
A	SER848
B	SER845
B	SER848
D	SER845
D	SER848

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
C	CYS595
C	CYS821
A	CYS595
A	CYS821
B	CYS595
B	CYS821
D	CYS595
D	CYS821

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873

Chain	Residue	Details
C	ASN241
A	ASN241
B	ASN241
D	ASN241

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405

Chain	Residue	Details
C	ASN355
A	ASN355
B	ASN355
D	ASN355

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN391
C	ASN398
A	ASN391
A	ASN398
B	ASN391
B	ASN398
D	ASN391
D	ASN398

---