6U6F
The crystal structure of anti-apoptotic Mcl-1 protein in complex with 2, 5-substituted benzoic acid inhibitor 21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 156 | 17838.2 | 3 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | D, E, F, G (A, B, C) | 2-[({4-[(4-tert-butylphenyl)methyl]piperazin-1-yl}sulfonyl)amino]-5-[(2-phenylethyl)sulfanyl]benzoic acid | non-polymer | 567.8 | 4 | Chemie (PZY) | |||
| 3 | H, I, J (A, B, C) | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A, B, C: 171 - 323 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Ser 168 | - | expression tag |
| Asn 169 | - | expression tag |
| Ala 170 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53514.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2271.0 | |
| All* | Total formula weight | 55785.7 |
