6U5O

Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (L)	RNA-directed RNA polymerase L	polymer	2030	233889.6	1	UniProt (Q6WB93) Pfam (PF00946) Pfam (PF14318) Pfam (PF14314)	Human metapneumovirus (strain CAN97-83) (HMPV)	Protein L,Large structural protein,Replicase,Transcriptase
2	B, C, D, E (P, Q, R, S)	Phosphoprotein	polymer	319	35685.1	4	UniProt (Q8B9Q8) Pfam (PF02478)	Human metapneumovirus (strain CAN97-83) (HMPV)	Protein P

Sequence modifications

L: 1 - 2005 (UniProt: Q6WB93)

PDB	External Database	Details
Met -24	-	initiating methionine
Gly -23	-	expression tag
Trp -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
Pro -19	-	expression tag
Gln -18	-	expression tag
Phe -17	-	expression tag
Glu -16	-	expression tag
Lys -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

P, Q, R, S: 1 - 294 (UniProt: Q8B9Q8)

PDB	External Database	Details
Met -24	-	initiating methionine
Gly -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	376629.8
All*	Total formula weight	376629.8

*Water molecules are not included.