6U5O

Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0000166	molecular_function	nucleotide binding
L	0001172	biological_process	RNA-templated transcription
L	0003824	molecular_function	catalytic activity
L	0003924	molecular_function	GTPase activity
L	0003968	molecular_function	RNA-dependent RNA polymerase activity
L	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
L	0005524	molecular_function	ATP binding
L	0006370	biological_process	7-methylguanosine mRNA capping
L	0006397	biological_process	mRNA processing
L	0008152	biological_process	metabolic process
L	0008168	molecular_function	methyltransferase activity
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0016787	molecular_function	hydrolase activity
L	0030430	cellular_component	host cell cytoplasm
L	0032259	biological_process	methylation
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0044423	cellular_component	virion component
L	0046872	molecular_function	metal ion binding
L	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
P	0001172	biological_process	RNA-templated transcription
P	0003968	molecular_function	RNA-dependent RNA polymerase activity
P	0030430	cellular_component	host cell cytoplasm
P	0044423	cellular_component	virion component
Q	0001172	biological_process	RNA-templated transcription
Q	0003968	molecular_function	RNA-dependent RNA polymerase activity
Q	0030430	cellular_component	host cell cytoplasm
Q	0044423	cellular_component	virion component
R	0001172	biological_process	RNA-templated transcription
R	0003968	molecular_function	RNA-dependent RNA polymerase activity
R	0030430	cellular_component	host cell cytoplasm
R	0044423	cellular_component	virion component
S	0001172	biological_process	RNA-templated transcription
S	0003968	molecular_function	RNA-dependent RNA polymerase activity
S	0030430	cellular_component	host cell cytoplasm
S	0044423	cellular_component	virion component

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03421

Chain	Residue	Details
P	SER106
Q	SER158
Q	SER168
Q	SER171
R	SER106
R	SER148
R	SER157
R	SER158
R	SER168
R	SER171
S	SER106
P	SER148
S	SER148
S	SER157
S	SER158
S	SER168
S	SER171
P	SER157
P	SER158
P	SER168
P	SER171
Q	SER106
Q	SER148
Q	SER157

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For mRNA (nucleoside-2'-O-)-methyltransferase activity => ECO:0000269|PubMed:25056882

Chain	Residue	Details
L	LYS1673
L	ASP1779
L	LYS1817
L	GLU1848

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P28887

Chain	Residue	Details
L	ASP635

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:31698413

Chain	Residue	Details
L	ASP745

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25056882

Chain	Residue	Details
L	GLY1696

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