6U5O
Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| L | 0000166 | molecular_function | nucleotide binding |
| L | 0001172 | biological_process | RNA-templated transcription |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0003924 | molecular_function | GTPase activity |
| L | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| L | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| L | 0006397 | biological_process | mRNA processing |
| L | 0008168 | molecular_function | methyltransferase activity |
| L | 0016740 | molecular_function | transferase activity |
| L | 0016779 | molecular_function | nucleotidyltransferase activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0030430 | cellular_component | host cell cytoplasm |
| L | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0106005 | biological_process | RNA 5'-cap (guanine-N7)-methylation |
| P | 0001172 | biological_process | RNA-templated transcription |
| P | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| P | 0030430 | cellular_component | host cell cytoplasm |
| Q | 0001172 | biological_process | RNA-templated transcription |
| Q | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| Q | 0030430 | cellular_component | host cell cytoplasm |
| R | 0001172 | biological_process | RNA-templated transcription |
| R | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| R | 0030430 | cellular_component | host cell cytoplasm |
| S | 0001172 | biological_process | RNA-templated transcription |
| S | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| S | 0030430 | cellular_component | host cell cytoplasm |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 183 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 477 |
| Details | Region: {"description":"GDP polyribonucleotidyltransferase","evidences":[{"source":"UniProtKB","id":"P28887","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Region: {"description":"priming-capping loop","evidences":[{"source":"UniProtKB","id":"P03523","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for GDP polyribonucleotidyltransferase activity","evidences":[{"source":"UniProtKB","id":"P03523","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P28887","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31698413","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | Region: {"description":"Oligomerization and binding to RNA-directed RNA polymerase L","evidences":[{"source":"PubMed","id":"31698413","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
