6U5O

Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0000166	molecular_function	nucleotide binding
L	0001172	biological_process	RNA-templated transcription
L	0003824	molecular_function	catalytic activity
L	0003924	molecular_function	GTPase activity
L	0003968	molecular_function	RNA-directed RNA polymerase activity
L	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
L	0005524	molecular_function	ATP binding
L	0006370	biological_process	7-methylguanosine mRNA capping
L	0006397	biological_process	mRNA processing
L	0008168	molecular_function	methyltransferase activity
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0016787	molecular_function	hydrolase activity
L	0030430	cellular_component	host cell cytoplasm
L	0032259	biological_process	methylation
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0044423	cellular_component	virion component
L	0046872	molecular_function	metal ion binding
L	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
P	0001172	biological_process	RNA-templated transcription
P	0003968	molecular_function	RNA-directed RNA polymerase activity
P	0030430	cellular_component	host cell cytoplasm
P	0044423	cellular_component	virion component
Q	0001172	biological_process	RNA-templated transcription
Q	0003968	molecular_function	RNA-directed RNA polymerase activity
Q	0030430	cellular_component	host cell cytoplasm
Q	0044423	cellular_component	virion component
R	0001172	biological_process	RNA-templated transcription
R	0003968	molecular_function	RNA-directed RNA polymerase activity
R	0030430	cellular_component	host cell cytoplasm
R	0044423	cellular_component	virion component
S	0001172	biological_process	RNA-templated transcription
S	0003968	molecular_function	RNA-directed RNA polymerase activity
S	0030430	cellular_component	host cell cytoplasm
S	0044423	cellular_component	virion component

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	183
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	477
Details	Region: {"description":"GDP polyribonucleotidyltransferase","evidences":[{"source":"UniProtKB","id":"P28887","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Nucleophile; for GDP polyribonucleotidyltransferase activity","evidences":[{"source":"UniProtKB","id":"P03523","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P28887","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31698413","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	50
Details	Region: {"description":"Oligomerization and binding to RNA-directed RNA polymerase L","evidences":[{"source":"PubMed","id":"31698413","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03421","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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