6U4Y

Crystal Structure of an EZH2-EED Complex in an Oligomeric State

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Histone-lysine N-methyltransferase EZH2	polymer	224	25701.2	3	UniProt (Q15910) Pfam (PF11616) Pfam (PF18118)	Homo sapiens (Human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2	D, E, F (D, E, F)	Polycomb protein EED	polymer	366	42185.0	3	UniProt (O75530) Pfam (PF00400)	Homo sapiens (Human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1

Sequence modifications

A, B, C: 2 - 215 (UniProt: Q15910)

PDB	External Database	Details
Ser 1	-	expression tag
Ser 72	Thr 72	conflict

A, B, C: 220 - 257 (UniProt: Q15910)

PDB	External Database	Details
Gly 216	-	linker
Ser 217	-	linker
Ser 218	-	linker
Gly 219	-	linker

D, E, F: 78 - 441 (UniProt: O75530)

PDB	External Database	Details
Gly 76	-	expression tag
Ser 77	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	203658.4
All*	Total formula weight	203658.4

*Water molecules are not included.