6TWB
Crystal Structure of the Catalytic Domain of Coagulation Factor XIa in Complex with Double Bridged Peptide F19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, H) | Coagulation factor XI | polymer | 262 | 29741.7 | 2 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (Human) | FXI,Plasma thromboplastin antecedent,PTA |
| 2 | C (B) | Double Bridged Peptide F19 | polymer | 11 | 1252.6 | 1 | synthetic construct | ||
| 3 | D, E, F (A, B) | AMMONIUM ION | non-polymer | 18.0 | 3 | Chemie (NH4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, H: 3 - 245 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Gly 113 | Asn 437 | conflict |
| Gly 115 | Thr 439 | conflict |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60736.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 54.1 | |
| All* | Total formula weight | 60790.2 |
