6TWB

Crystal Structure of the Catalytic Domain of Coagulation Factor XIa in Complex with Double Bridged Peptide F19

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, H	Coagulation factor XI	polymer	262	29741.7	2	UniProt (P03951) Pfam (PF00089) In PDB	Homo sapiens (Human)	FXI,Plasma thromboplastin antecedent,PTA
2	B	Double Bridged Peptide F19	polymer	11	1252.6	1		synthetic construct
3	A, B	AMMONIUM ION	non-polymer		18.0	3	Chemie (NH4)
4		water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, H: 3 - 245 (UniProt: P03951)

PDB	External Database	Details
Met -2	-	initiating methionine
Asp -1	-	expression tag
Asp 0	-	expression tag
Asp 1	-	expression tag
Asp 2	-	expression tag
Gly 113	Asn 437	conflict
Gly 115	Thr 439	conflict
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	60736.1
Non-Polymers*	Number of molecules	3
	Total formula weight	54.1
All*	Total formula weight	60790.2

*Water molecules are not included.