6TWB

Crystal Structure of the Catalytic Domain of Coagulation Factor XIa in Complex with Double Bridged Peptide F19

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue NH4 A 301

Chain	Residue
A	ARG24
A	LYS175

---

site_id	AC2
Number of Residues	1
Details	binding site for residue NH4 A 302

Chain	Residue
A	HIS178

---

site_id	AC3
Number of Residues	2
Details	binding site for residue NH4 B 101

Chain	Residue
B	CSA1
B	VAL2

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site_id	AC4
Number of Residues	4
Details	binding site for Di-peptide CSA B 1 and VAL B 2

Chain	Residue
A	GLN118
B	ASN3
B	CYS7
B	NH4101

---

site_id	AC5
Number of Residues	10
Details	binding site for Di-peptide CSA B 1 and CYS B 7

Chain	Residue
A	LYS192
A	GLY218
B	VAL2
B	ASN3
B	ILE4
B	MET5
B	CSA6
B	ARG8
B	CYS9
B	NH4101

---

site_id	AC6
Number of Residues	14
Details	binding site for Di-peptide MET B 5 and CSA B 6

Chain	Residue
A	HIS57
A	ALA97
A	GLU98
A	TYR171
A	HIS174
A	SER214
A	TRP215
A	GLY216
A	GLU217
B	ASN3
B	ILE4
B	CYS7
B	ARG8
B	CYS9

---

site_id	AC7
Number of Residues	12
Details	binding site for Di-peptide CSA B 6 and CYS B 9

Chain	Residue
A	HIS57
A	ALA97
A	LYS192
A	SER195
A	SER214
B	ASN3
B	ILE4
B	MET5
B	CYS7
B	ARG8
B	PRO10
B	NH211

---

site_id	AC8
Number of Residues	11
Details	binding site for Di-peptide CSA B 6 and CYS B 7

Chain	Residue
A	HIS57
A	ALA97
A	LYS192
A	SER214
A	GLY218
B	CSA1
B	ASN3
B	ILE4
B	MET5
B	ARG8
B	CYS9

---

site_id	AC9
Number of Residues	6
Details	binding site for Di-peptide PRO B 10 and NH2 B 11

Chain	Residue
A	ARG39
A	LEU41
A	LYS192
A	SER195
A	HOH401
B	CYS9

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLS

Chain	Residue	Details
A	ASP189-SER200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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