6TDC

PPAR gamma ligand binding domain in complex with MRL-871

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peroxisome proliferator-activated receptor gamma	polymer	292	33299.6	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	A	4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid	non-polymer		444.8	1	Chemie (4F1)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	39	Chemie (HOH)

Sequence modifications

A: 235 - 505 (UniProt: P37231)

PDB	External Database	Details
Met 214	-	initiating methionine
Gly 215	-	expression tag
Ser 216	-	expression tag
Ser 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
Ser 224	-	expression tag
Ser 225	-	expression tag
Gly 226	-	expression tag
Leu 227	-	expression tag
Val 228	-	expression tag
Pro 229	-	expression tag
Arg 230	-	expression tag
Gly 231	-	expression tag
Ser 232	-	expression tag
His 233	-	expression tag
Met 234	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33299.6
Non-Polymers*	Number of molecules	2
	Total formula weight	536.9
All*	Total formula weight	33836.5

*Water molecules are not included.