6TBM
Structure of SAGA bound to TBP, including Spt8 and DUB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (M) | TATA-box Binding Protein (TBP) | polymer | 240 | 27042.3 | 1 | Pfam (PF00352) UniProt (by SIFTS) (P13393) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 2 | B (A) | Transcriptional coactivator HFI1/ADA1 | polymer | 448 | 49888.3 | 1 | UniProt (C4QZA3) Pfam (PF12767) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 3 | C (C) | Subunit of SAGA histone acetyltransferase complex | polymer | 698 | 79995.2 | 1 | UniProt (C4QZ39) Pfam (PF08313) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast Pichia pastoris) | |
| 4 | D (F) | Spt20 | polymer | 517 | 59530.6 | 1 | UniProt (C4QZ05) Pfam (PF12090) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 5 | E (D) | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to act | polymer | 341 | 39030.1 | 1 | UniProt (C4R3E4) Pfam (PF02269) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 6 | F (E) | Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex | polymer | 1191 | 136768.8 | 1 | UniProt (C4R5C7) Pfam (PF00439) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 7 | G (J) | Transcription initiation factor TFIID subunit 10 | polymer | 217 | 23879.1 | 1 | UniProt (C4QXP2) Pfam (PF03540) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 8 | H (K) | Subunit (61/68 kDa) of TFIID and SAGA complexes | polymer | 609 | 66690.1 | 1 | UniProt (C4R150) Pfam (PF03847) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 9 | I (G) | Subunit (90 kDa) of TFIID and SAGA complexes | polymer | 722 | 80933.0 | 1 | UniProt (C4R4L4) Pfam (PF00400) Pfam (PF08513) Pfam (PF04494) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 10 | J (H) | Subunit (60 kDa) of TFIID and SAGA complexes | polymer | 485 | 54888.4 | 1 | UniProt (C4QW33) Pfam (PF02969) Pfam (PF07571) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 11 | K (I) | Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation | polymer | 153 | 17303.6 | 1 | UniProt (C4QZS5) Pfam (PF02291) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 12 | L (L) | Transcription-associated protein | polymer | 3825 | 438055.3 | 1 | UniProt (C4QYV4) Pfam (PF20175) Pfam (PF20206) Pfam (PF02259) Pfam (PF00454) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 13 | M (B) | Transcriptional regulator involved in glucose repression of Gal4p-regulated genes | polymer | 722 | 81864.3 | 1 | UniProt (C4R2A4) Pfam (PF10198) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 14 | N (N) | Spt8 | polymer | 400 | 34059.9 | 1 | Komagataella phaffii GS115 (Yeast) | ||
| 15 | O (R) | Polyubiquitin-B | polymer | 76 | 8560.8 | 1 | UniProt (J3QS39) Pfam (PF00240) UniProt (by SIFTS) (P0CG47) | Homo sapiens (Human) | |
| 16 | P (Q) | Ubiquitin carboxyl-terminal hydrolase | polymer | 502 | 56745.9 | 1 | UniProt (C4QY61) Pfam (PF02148) Pfam (PF00443) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 17 | Q (O) | SAGA-associated factor 11 | polymer | 123 | 13977.7 | 1 | UniProt (C4R2D9) Pfam (PF08209) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 18 | R (P) | Transcription and mRNA export factor SUS1 | polymer | 96 | 11126.7 | 1 | UniProt (C4R1P1) Pfam (PF10163) | Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) | |
| 19 | S, T (R, Q) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
C: -8 - 644 (UniProt: C4QZ39)
R: 1 - 75 (UniProt: J3QS39)
| PDB | External Database | Details |
|---|---|---|
| Leu 645 | - | expression tag |
| Glu 646 | - | expression tag |
| Gly 647 | - | expression tag |
| Gly 648 | - | expression tag |
| Gly 649 | - | expression tag |
| Gly 650 | - | expression tag |
| Ser 651 | - | expression tag |
| Met 652 | - | expression tag |
| Asp 653 | - | expression tag |
| Glu 654 | - | expression tag |
| Lys 655 | - | expression tag |
| Thr 656 | - | expression tag |
| Thr 657 | - | expression tag |
| Gly 658 | - | expression tag |
| Trp 659 | - | expression tag |
| Arg 660 | - | expression tag |
| Gly 661 | - | expression tag |
| Gly 662 | - | expression tag |
| His 663 | - | expression tag |
| Val 664 | - | expression tag |
| Val 665 | - | expression tag |
| Glu 666 | - | expression tag |
| Gly 667 | - | expression tag |
| Leu 668 | - | expression tag |
| Ala 669 | - | expression tag |
| Gly 670 | - | expression tag |
| Glu 671 | - | expression tag |
| Leu 672 | - | expression tag |
| Glu 673 | - | expression tag |
| Gln 674 | - | expression tag |
| Leu 675 | - | expression tag |
| Arg 676 | - | expression tag |
| Ala 677 | - | expression tag |
| Arg 678 | - | expression tag |
| Leu 679 | - | expression tag |
| Glu 680 | - | expression tag |
| His 681 | - | expression tag |
| His 682 | - | expression tag |
| Pro 683 | - | expression tag |
| Gln 684 | - | expression tag |
| Gly 685 | - | expression tag |
| Gln 686 | - | expression tag |
| Arg 687 | - | expression tag |
| Glu 688 | - | expression tag |
| Pro 689 | - | expression tag |
| Gly 690 | - | expression tag |
| Gly 691 | - | expression tag |
| Ser 692 | - | expression tag |
| His 693 | - | expression tag |
| His 694 | - | expression tag |
| His 695 | - | expression tag |
| His 696 | - | expression tag |
| His 697 | - | expression tag |
| His 698 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glz 76 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 1280340.3 | |
| All* | Total formula weight | 1280340.3 |
