6TBM

Structure of SAGA bound to TBP, including Spt8 and DUB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000124	cellular_component	SAGA complex
A	0003712	molecular_function	transcription coregulator activity
A	0003713	molecular_function	transcription coactivator activity
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006366	biological_process	transcription by RNA polymerase II
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046695	cellular_component	SLIK (SAGA-like) complex
A	0070461	cellular_component	SAGA-type complex
B	0000124	cellular_component	SAGA complex
B	0003713	molecular_function	transcription coactivator activity
B	0005634	cellular_component	nucleus
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0000124	cellular_component	SAGA complex
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
C	1904802	biological_process	RITS complex assembly
D	0000124	cellular_component	SAGA complex
D	0003712	molecular_function	transcription coregulator activity
D	0006366	biological_process	transcription by RNA polymerase II
D	0043229	cellular_component	intracellular organelle
D	0046982	molecular_function	protein heterodimerization activity
E	0000124	cellular_component	SAGA complex
E	0005198	molecular_function	structural molecule activity
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0046695	cellular_component	SLIK (SAGA-like) complex
E	0046982	molecular_function	protein heterodimerization activity
F	0000124	cellular_component	SAGA complex
F	0003712	molecular_function	transcription coregulator activity
F	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0005634	cellular_component	nucleus
G	0005669	cellular_component	transcription factor TFIID complex
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
G	0080090	biological_process	regulation of primary metabolic process
H	0000124	cellular_component	SAGA complex
H	0003682	molecular_function	chromatin binding
H	0005634	cellular_component	nucleus
H	0005669	cellular_component	transcription factor TFIID complex
H	0005829	cellular_component	cytosol
H	0006325	biological_process	chromatin organization
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0042802	molecular_function	identical protein binding
H	0043227	cellular_component	membrane-bounded organelle
H	0043229	cellular_component	intracellular organelle
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046695	cellular_component	SLIK (SAGA-like) complex
H	0046982	molecular_function	protein heterodimerization activity
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060090	molecular_function	molecular adaptor activity
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	2000144	biological_process	positive regulation of DNA-templated transcription initiation
I	0000124	cellular_component	SAGA complex
I	0003682	molecular_function	chromatin binding
I	0003713	molecular_function	transcription coactivator activity
I	0005634	cellular_component	nucleus
I	0005669	cellular_component	transcription factor TFIID complex
I	0006325	biological_process	chromatin organization
I	0006352	biological_process	DNA-templated transcription initiation
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006366	biological_process	transcription by RNA polymerase II
I	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
I	0042802	molecular_function	identical protein binding
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046695	cellular_component	SLIK (SAGA-like) complex
I	0046982	molecular_function	protein heterodimerization activity
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060090	molecular_function	molecular adaptor activity
J	0000124	cellular_component	SAGA complex
J	0003682	molecular_function	chromatin binding
J	0005634	cellular_component	nucleus
J	0005669	cellular_component	transcription factor TFIID complex
J	0006325	biological_process	chromatin organization
J	0006352	biological_process	DNA-templated transcription initiation
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
J	0042802	molecular_function	identical protein binding
J	0043229	cellular_component	intracellular organelle
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046695	cellular_component	SLIK (SAGA-like) complex
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060090	molecular_function	molecular adaptor activity
J	1990841	molecular_function	promoter-specific chromatin binding
K	0000124	cellular_component	SAGA complex
K	0003677	molecular_function	DNA binding
K	0005634	cellular_component	nucleus
K	0005669	cellular_component	transcription factor TFIID complex
K	0006352	biological_process	DNA-templated transcription initiation
K	0017025	molecular_function	TBP-class protein binding
K	0046982	molecular_function	protein heterodimerization activity
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0000126	cellular_component	transcription factor TFIIIB complex
M	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
M	0001016	molecular_function	RNA polymerase III transcription regulatory region sequence-specific DNA binding
M	0001092	molecular_function	TFIIA-class transcription factor complex binding
M	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
M	0001188	biological_process	RNA polymerase I preinitiation complex assembly
M	0003677	molecular_function	DNA binding
M	0003682	molecular_function	chromatin binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005667	cellular_component	transcription regulator complex
M	0005669	cellular_component	transcription factor TFIID complex
M	0005672	cellular_component	transcription factor TFIIA complex
M	0006352	biological_process	DNA-templated transcription initiation
M	0006359	biological_process	regulation of transcription by RNA polymerase III
M	0008301	molecular_function	DNA binding, bending
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0032991	cellular_component	protein-containing complex
M	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
M	0070898	biological_process	RNA polymerase III preinitiation complex assembly
M	0097718	molecular_function	disordered domain specific binding
M	0140297	molecular_function	DNA-binding transcription factor binding
O	0005634	cellular_component	nucleus
O	0046872	molecular_function	metal ion binding
O	0070461	cellular_component	SAGA-type complex
P	0000124	cellular_component	SAGA complex
P	0000932	cellular_component	P-body
P	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
P	0003682	molecular_function	chromatin binding
P	0003713	molecular_function	transcription coactivator activity
P	0005634	cellular_component	nucleus
P	0005643	cellular_component	nuclear pore
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0006325	biological_process	chromatin organization
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0006406	biological_process	mRNA export from nucleus
P	0008047	molecular_function	enzyme activator activity
P	0015031	biological_process	protein transport
P	0016973	biological_process	poly(A)+ mRNA export from nucleus
P	0032880	biological_process	regulation of protein localization
P	0043229	cellular_component	intracellular organelle
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0046695	cellular_component	SLIK (SAGA-like) complex
P	0051028	biological_process	mRNA transport
P	0070390	cellular_component	transcription export complex 2
P	0071028	biological_process	nuclear mRNA surveillance
P	0071819	cellular_component	DUBm complex
Q	0000124	cellular_component	SAGA complex
Q	0004843	molecular_function	cysteine-type deubiquitinase activity
Q	0006508	biological_process	proteolysis
Q	0008234	molecular_function	cysteine-type peptidase activity
Q	0008270	molecular_function	zinc ion binding
Q	0016579	biological_process	protein deubiquitination
Q	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSDSSNILTseDY

Chain	Residue	Details
L	ASP2069-TYR2081

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site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
R	LYS27-ASP52

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site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePKttaLIFaSGKMvvtGAKseddsklAsrkyariI

Chain	Residue	Details
M	TYR94-ILE143
M	TYR185-LEU234

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site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. StaFlnrvSkreap..NYYqiIkkpMdlntVmkklksfq..Ykskqefvddlml.IwkNCltY

Chain	Residue	Details
E	SER464-TYR521

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LFTGssDkTARMWDI

Chain	Residue	Details
G	LEU552-ILE566
G	LEU594-ILE608
G	LEU637-VAL651

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site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GFinmGAtCFMSSiVQ

Chain	Residue	Details
Q	GLY186-GLN201

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site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YqLfAIviHiGsvnt..GHY

Chain	Residue	Details
Q	TYR443-TYR460

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