6TA2

Human NAMPT in complex with nicotinic acid mononucleotide and phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Nicotinamide phosphoribosyltransferase	polymer	503	57000.5	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (Human)	Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	D, F (B, A)	NICOTINATE MONONUCLEOTIDE	non-polymer		335.2	2	Chemie (NCN)
4	E, G (B, A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
5	H, I (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	J, K (B, A)	water	water		18.0	1005	Chemie (HOH)

Sequence modifications

B, A: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Met -11	-	initiating methionine
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114000.9
Non-Polymers*	Number of molecules	7
	Total formula weight	1023.3
All*	Total formula weight	115024.3

*Water molecules are not included.