6T6A
Crystal structure of DYRK1A complexed with KuFal319 (compound 11)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 361 | 42081.5 | 4 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
| 2 | E, F, G, L, R (A, B, C) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 5 | Chemie (PG4) | |||
| 3 | H, I, J, M, N... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 4 | K, Q, W (A, B, C) | 4-chloranyl-5~{H}-cyclohepta[b]indol-10-one | non-polymer | 229.7 | 3 | Chemie (MLW) | |||
| 5 | AA, BA, CA, Z (B, C, D, A) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 127 - 485 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168326.1 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2908.9 | |
| All* | Total formula weight | 171235.1 |
