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6T6A

Crystal structure of DYRK1A complexed with KuFal319 (compound 11)

Summary for 6T6A
Entry DOI10.2210/pdb6t6a/pdb
DescriptorDual specificity tyrosine-phosphorylation-regulated kinase 1A, TETRAETHYLENE GLYCOL, SULFATE ION, ... (5 entities in total)
Functional Keywordsdyrk1a, splicing kinase, kinase inhibitor, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight171235.08
Authors
Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-18, release date: 2019-12-04, Last modification date: 2024-01-24)
Primary citationLechner, C.,Flasshoff, M.,Falke, H.,Preu, L.,Loaec, N.,Meijer, L.,Knapp, S.,Chaikuad, A.,Kunick, C.
[ b ]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.
Molecules, 24:-, 2019
Cited by
PubMed: 31766108
DOI: 10.3390/molecules24224090
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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