6SSI
Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Cys-loop ligand-gated ion channel | polymer | 318 | 36465.6 | 5 | UniProt (P0C7B7) | Dickeya chrysanthemi (Pectobacterium chrysanthemi) | ELIC |
| 2 | F, G, H, I, J (F, G, H, I, J) | NANOBODY 22 | polymer | 121 | 13316.7 | 5 | Lama glama | ||
| 3 | BA, HA, K, O, V (D, E, A, B, C) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 5 | Chemie (ABU) PubChem (119) | |||
| 4 | CA, IA, L, P, W (D, E, A, B, C) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 5 | Chemie (MES) PubChem (4478249) | |||
| 5 | DA, JA, KA, M, Q... (D, E, A, B, C) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) PubChem (753) | |||
| 6 | FA, MA, N, S, Z (D, E, A, B, C) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) PubChem (271) | |||
| 7 | EA, LA, R, Y (D, E, B, C) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) PubChem (8200) | |||
| 8 | AA, OA, PA, T, U (C, E, B) | UNDECYL-MALTOSIDE | non-polymer | 496.6 | 5 | Chemie (UMQ) PubChem (447793) PubChem (5076192) PubChem (44462510) PubChem (46936455) PubChem (70699426) PubChem (70699431) PubChem (70796434) PubChem (71300307) PubChem (124643296) PubChem (58112566) PubChem (59518662) PubChem (68343856) PubChem (70699429) PubChem (70701336) PubChem (70701337) PubChem (70839940) PubChem (70841479) PubChem (70863062) PubChem (71300308) PubChem (89952000) PubChem (92132109) PubChem (126731015) PubChem (126731038) PubChem (126735855) PubChem (126735857) PubChem (131632466) PubChem (169544249) | |||
| 9 | GA, NA (D, E) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) PubChem (175) | |||
| 10 | QA, RA, SA, TA, UA... (A, B, C, D, E...) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 8 - 321 (UniProt: P0C7B7)
| PDB | External Database | Details |
|---|---|---|
| Gly 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Val 7 | - | expression tag |
| Gly 164 | - | insertion |
| Asn 289 | Met 288 | conflict |
| Gly 322 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 248911.5 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 5622.7 | |
| All* | Total formula weight | 254534.2 |
