6SIV
Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3 | polymer | 383 | 41804.2 | 1 | UniProt (P0AEX9) UniProt (Q14653) Pfam (PF01547) | Escherichia coli (strain K12) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,IRF-3 |
| 2 | B (B) | Protein E6 | polymer | 153 | 18439.3 | 1 | UniProt (P03126) Pfam (PF00518) | Human papillomavirus type 16 | |
| 3 | C (C) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 828.7 | 1 | In PDB BIRD (PRD_900030) GlyTouCan (G50146AM) | alpha-maltopentaose | ||
| 4 | D, E (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A: 1 - 362 (UniProt: P0AEX9)
A: 2137 - 2148 (UniProt: Q14653)
B: 999 - 1151 (UniProt: P03126)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | Ala 26 | conflict |
| Ala 83 | Asp 108 | conflict |
| Ala 84 | Lys 109 | engineered mutation |
| Ala 240 | Lys 265 | engineered mutation |
| Ala 360 | Glu 385 | engineered mutation |
| Ala 363 | - | linker |
| Ala 364 | - | linker |
| Ala 365 | - | linker |
| Gln 366 | - | linker |
| Thr 367 | - | linker |
| Asn 368 | - | linker |
| Ala 369 | - | linker |
| Ala 370 | - | linker |
| Ala 371 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Glu 2146 | Asn 146 | engineered mutation |
| Glu 2147 | Met 147 | engineered mutation |
| Arg 2148 | Val 148 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 999 | Thr 6 | conflict |
| Arg 1047 | Phe 54 | engineered mutation |
| Ser 1080 | Cys 87 | engineered mutation |
| Ser 1097 | Cys 104 | engineered mutation |
| Ser 1111 | Cys 118 | engineered mutation |
| Ser 1140 | Cys 147 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60243.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 828.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 61203.0 |
