6S9J
Crystal structure of TfR1 mimicry in complex with GP1 from MACV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (B, D, F, H) | Pre-glycoprotein polyprotein GP complex | polymer | 168 | 19343.8 | 4 | UniProt (Q8AZ57) Pfam (PF00798) | Machupo virus (MACV) | Pre-GP-C |
| 2 | B, D, F, H (A, C, E, G) | Transferrin receptor 1,Transferrin receptor 1 | polymer | 178 | 19651.2 | 4 | UniProt (A0A060BIS8) Pfam (PF02225) | Neotoma albigula (White-throated woodrat) | |
| 3 | I (I) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | J (J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K, L, M (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | N, O, P, Q, R... (B, A, D, C, F...) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 85 - 244 (UniProt: Q8AZ57)
A, C, E, G: 189 - 326 (UniProt: A0A060BIS8)
A, C, E, G: 327 - 383 (UniProt: A0A060BIS8)
| PDB | External Database | Details |
|---|---|---|
| Gly 245 | - | expression tag |
| Ser 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 194 | Gly 195 | conflict |
| - | Val 197 | deletion |
| Lys 283 | Met 284 | conflict |
| Tyr 288 | Phe 289 | conflict |
| Ser 291 | Val 292 | conflict |
| Glu 295 | Ile 296 | conflict |
| Gln 324 | Phe 299 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 380 | Ala 381 | conflict |
| Gly 384 | - | expression tag |
| Thr 385 | - | expression tag |
| Ser 386 | - | expression tag |
| Gly 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| His 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 155980.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1335.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 157978.9 |
