6S8S

Extended structure of the human DDX6 C-terminal domain in complex with an EDC3 FDF peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Probable ATP-dependent RNA helicase DDX6	polymer	193	22475.7	2	UniProt (P26196) Pfam (PF00271)	Homo sapiens (Human)	ATP-dependent RNA helicase p54,DEAD box protein 6,Oncogene RCK
2	B, D (B, D)	Enhancer of mRNA-decapping protein 3	polymer	44	5069.4	2	UniProt (Q96F86)	Homo sapiens (Human)	LSM16 homolog,YjeF N-terminal domain-containing protein 2,hYjeF_N2,YjeF domain-containing protein 1
3	E, F, G, H, I... (A, C, D)	PHOSPHATE ION	non-polymer		95.0	9	Chemie (PO4)
4	J, K, L, P, Q (A, C)	3-CYCLOHEXYL-1-PROPYLSULFONIC ACID	non-polymer		221.3	5	Chemie (CXS)
5	S, T, U, V (A, B, C, D)	water	water		18.0	258	Chemie (HOH)

Sequence modifications

A, C: 284 - 472 (UniProt: P26196)

PDB	External Database	Details
Gly 280	-	expression tag
Pro 281	-	expression tag
Gln 282	-	expression tag
Asp 283	-	expression tag

B, D: 192 - 228 (UniProt: Q96F86)

PDB	External Database	Details
Gly 185	-	expression tag
Pro 186	-	expression tag
His 187	-	expression tag
Met 188	-	expression tag
Ala 189	-	expression tag
Asp 190	-	expression tag
Leu 191	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55090.2
Non-Polymers*	Number of molecules	14
	Total formula weight	1961.3
All*	Total formula weight	57051.5

*Water molecules are not included.