6RZ7
Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (F222 space group)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2 | polymer | 405 | 45996.0 | 1 | UniProt (Q9NS75) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321,Cytochrome b-562,CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321 |
2 | A | (2~{S})-8-[[4-[4-(2-chloranyl-5-fluoranyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3- dihydro-1,4-benzoxazine-2-carboxylic acid | non-polymer | 585.0 | 1 | Chemie (KNW) | |||
3 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
4 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) | |||
5 | A | OLEIC ACID | non-polymer | 282.5 | 21 | Chemie (OLA) | |||
6 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
7 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 17 - 232 (UniProt: Q9NS75)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 240 - 322 (UniProt: Q9NS75)
PDB | External Database | Details |
---|---|---|
Val 51 | Trp 51 | engineered mutation |
Asn 84 | Asp 84 | engineered mutation |
Tyr 137 | Phe 137 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45996.0 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 7766.6 | |
All* | Total formula weight | 53762.6 |