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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RZ7

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (F222 space group)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004974	molecular_function	leukotriene receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue KNW A 2001

Chain	Residue
A	LYS37
A	MET201
A	ASN202
A	ILE204
A	GLY209
A	ARG267
A	LEU271
A	HIS284
A	HOH2104
A	HOH2120
A	TYR119
A	TYR123
A	SER169
A	SER170
A	LEU188
A	GLU189
A	LYS194
A	LEU198

site_id	AC2
Number of Residues	4
Details	binding site for residue CLR A 2002

Chain	Residue
A	SER218
A	THR265
A	OLA2006
A	HOH2101

site_id	AC3
Number of Residues	2
Details	binding site for residue OLC A 2003

Chain	Residue
A	TYR127
A	SER169

site_id	AC4
Number of Residues	6
Details	binding site for residue OLC A 2004

Chain	Residue
A	LEU85
A	LEU86
A	TRP156
A	OLA2010
A	OLA2015
A	OLA2020

site_id	AC5
Number of Residues	4
Details	binding site for residue OLA A 2005

Chain	Residue
A	ILE171
A	TYR203
A	LEU206
A	PHE215

site_id	AC6
Number of Residues	3
Details	binding site for residue OLA A 2006

Chain	Residue
A	PHE215
A	LEU222
A	CLR2002

site_id	AC7
Number of Residues	7
Details	binding site for residue OLA A 2007

Chain	Residue
A	ASN79
A	SER83
A	SER117
A	TRP163
A	MET167
A	OLA2010
A	OLA2014

site_id	AC8
Number of Residues	4
Details	binding site for residue OLA A 2008

Chain	Residue
A	PHE36
A	ILE47
A	LYS285
A	OLA2013

site_id	AC9
Number of Residues	5
Details	binding site for residue OLA A 2009

Chain	Residue
A	VAL53
A	TYR61
A	ALA319
A	LEU320
A	OLA2022

site_id	AD1
Number of Residues	5
Details	binding site for residue OLA A 2010

Chain	Residue
A	TRP156
A	OLC2004
A	OLA2007
A	OLA2014
A	OLA2020

site_id	AD2
Number of Residues	6
Details	binding site for residue OLA A 2011

Chain	Residue
A	LEU46
A	PHE49
A	ASP96
A	LEU99
A	LYS322
A	OLA2021

site_id	AD3
Number of Residues	7
Details	binding site for residue OLA A 2012

Chain	Residue
A	GLY107
A	ASP108
A	LEU109
A	ALA110
A	OLA2015
A	OLA2016
A	OLA2020

site_id	AD4
Number of Residues	3
Details	binding site for residue OLA A 2013

Chain	Residue
A	PHE36
A	GLU39
A	OLA2008

site_id	AD5
Number of Residues	3
Details	binding site for residue OLA A 2014

Chain	Residue
A	GLY160
A	OLA2007
A	OLA2010

site_id	AD6
Number of Residues	4
Details	binding site for residue OLA A 2015

Chain	Residue
A	LEU64
A	OLC2004
A	OLA2012
A	OLA2016

site_id	AD7
Number of Residues	6
Details	binding site for residue OLA A 2016

Chain	Residue
A	PHE93
A	ILE105
A	GLY107
A	OLA2012
A	OLA2015
A	OLA2017

site_id	AD8
Number of Residues	3
Details	binding site for residue OLA A 2017

Chain	Residue
A	ILE105
A	OLA2016
A	OLA2022

site_id	AD9
Number of Residues	3
Details	binding site for residue OLA A 2018

Chain	Residue
A	TYR221
A	THR265
A	OLA2023

site_id	AE1
Number of Residues	3
Details	binding site for residue OLA A 2019

Chain	Residue
A	THR247
A	ILE250
A	PHE307

site_id	AE2
Number of Residues	3
Details	binding site for residue OLA A 2020

Chain	Residue
A	OLC2004
A	OLA2010
A	OLA2012

site_id	AE3
Number of Residues	3
Details	binding site for residue OLA A 2021

Chain	Residue
A	ASP96
A	ARG100
A	OLA2011

site_id	AE4
Number of Residues	4
Details	binding site for residue OLA A 2022

Chain	Residue
A	LEU64
A	GLN65
A	OLA2009
A	OLA2017

site_id	AE5
Number of Residues	3
Details	binding site for residue OLA A 2023

Chain	Residue
A	GLU232
A	ALA286
A	OLA2018

site_id	AE6
Number of Residues	3
Details	binding site for residue OLA A 2024

Chain	Residue
A	ILE164
A	PHE215
A	LEU223

site_id	AE7
Number of Residues	1
Details	binding site for residue OLA A 2025

Chain	Residue
A	LEU258

site_id	AE8
Number of Residues	2
Details	binding site for residue PGE A 2026

Chain	Residue
A	TRP1007
A	ASN1099

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	ILE43-PHE63

site_id	SWS_FT_FI2
Number of Residues	16
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LEU64-SER72
A	ARG145-ARG153

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	VAL73-PHE93

site_id	SWS_FT_FI4
Number of Residues	77
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	ARG94-TYR123
A	ASP175-ILE204
A	ARG267-ALA286

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	SER124-PHE144

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	SER154-LEU174

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	ALA205-ILE225

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	LEU246-LEU266

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	LEU287-PHE307

site_id	SWS_FT_FI10
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN20
A	ASN26
A	ASN30
A	ASN181

site_id	SWS_FT_FI11
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

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PDB entries from 2024-07-17

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