6RZ7

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (F222 space group)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004974	molecular_function	leukotriene receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue KNW A 2001

Chain	Residue
A	LYS37
A	MET201
A	ASN202
A	ILE204
A	GLY209
A	ARG267
A	LEU271
A	HIS284
A	HOH2104
A	HOH2120
A	TYR119
A	TYR123
A	SER169
A	SER170
A	LEU188
A	GLU189
A	LYS194
A	LEU198

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CLR A 2002

Chain	Residue
A	SER218
A	THR265
A	OLA2006
A	HOH2101

---

site_id	AC3
Number of Residues	2
Details	binding site for residue OLC A 2003

Chain	Residue
A	TYR127
A	SER169

---

site_id	AC4
Number of Residues	6
Details	binding site for residue OLC A 2004

Chain	Residue
A	LEU85
A	LEU86
A	TRP156
A	OLA2010
A	OLA2015
A	OLA2020

---

site_id	AC5
Number of Residues	4
Details	binding site for residue OLA A 2005

Chain	Residue
A	ILE171
A	TYR203
A	LEU206
A	PHE215

---

site_id	AC6
Number of Residues	3
Details	binding site for residue OLA A 2006

Chain	Residue
A	PHE215
A	LEU222
A	CLR2002

---

site_id	AC7
Number of Residues	7
Details	binding site for residue OLA A 2007

Chain	Residue
A	ASN79
A	SER83
A	SER117
A	TRP163
A	MET167
A	OLA2010
A	OLA2014

---

site_id	AC8
Number of Residues	4
Details	binding site for residue OLA A 2008

Chain	Residue
A	PHE36
A	ILE47
A	LYS285
A	OLA2013

---

site_id	AC9
Number of Residues	5
Details	binding site for residue OLA A 2009

Chain	Residue
A	VAL53
A	TYR61
A	ALA319
A	LEU320
A	OLA2022

---

site_id	AD1
Number of Residues	5
Details	binding site for residue OLA A 2010

Chain	Residue
A	TRP156
A	OLC2004
A	OLA2007
A	OLA2014
A	OLA2020

---

site_id	AD2
Number of Residues	6
Details	binding site for residue OLA A 2011

Chain	Residue
A	LEU46
A	PHE49
A	ASP96
A	LEU99
A	LYS322
A	OLA2021

---

site_id	AD3
Number of Residues	7
Details	binding site for residue OLA A 2012

Chain	Residue
A	GLY107
A	ASP108
A	LEU109
A	ALA110
A	OLA2015
A	OLA2016
A	OLA2020

---

site_id	AD4
Number of Residues	3
Details	binding site for residue OLA A 2013

Chain	Residue
A	PHE36
A	GLU39
A	OLA2008

---

site_id	AD5
Number of Residues	3
Details	binding site for residue OLA A 2014

Chain	Residue
A	GLY160
A	OLA2007
A	OLA2010

---

site_id	AD6
Number of Residues	4
Details	binding site for residue OLA A 2015

Chain	Residue
A	LEU64
A	OLC2004
A	OLA2012
A	OLA2016

---

site_id	AD7
Number of Residues	6
Details	binding site for residue OLA A 2016

Chain	Residue
A	PHE93
A	ILE105
A	GLY107
A	OLA2012
A	OLA2015
A	OLA2017

---

site_id	AD8
Number of Residues	3
Details	binding site for residue OLA A 2017

Chain	Residue
A	ILE105
A	OLA2016
A	OLA2022

---

site_id	AD9
Number of Residues	3
Details	binding site for residue OLA A 2018

Chain	Residue
A	TYR221
A	THR265
A	OLA2023

---

site_id	AE1
Number of Residues	3
Details	binding site for residue OLA A 2019

Chain	Residue
A	THR247
A	ILE250
A	PHE307

---

site_id	AE2
Number of Residues	3
Details	binding site for residue OLA A 2020

Chain	Residue
A	OLC2004
A	OLA2010
A	OLA2012

---

site_id	AE3
Number of Residues	3
Details	binding site for residue OLA A 2021

Chain	Residue
A	ASP96
A	ARG100
A	OLA2011

---

site_id	AE4
Number of Residues	4
Details	binding site for residue OLA A 2022

Chain	Residue
A	LEU64
A	GLN65
A	OLA2009
A	OLA2017

---

site_id	AE5
Number of Residues	3
Details	binding site for residue OLA A 2023

Chain	Residue
A	GLU232
A	ALA286
A	OLA2018

---

site_id	AE6
Number of Residues	3
Details	binding site for residue OLA A 2024

Chain	Residue
A	ILE164
A	PHE215
A	LEU223

---

site_id	AE7
Number of Residues	1
Details	binding site for residue OLA A 2025

Chain	Residue
A	LEU258

---

site_id	AE8
Number of Residues	2
Details	binding site for residue PGE A 2026

Chain	Residue
A	TRP1007
A	ASN1099

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---