6RUR

Structure of the SCIN stabilized C3bBb convertase bound to properdin

Replaces:  5M6W

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (U, X)	Properdin	polymer	234	25494.7	2	UniProt (P27918) Pfam (PF18487) Pfam (PF00090)	Homo sapiens (Human)	Complement factor P
2	B, D (V, Y)	Properdin	polymer	215	23929.3	2	UniProt (P27918) Pfam (PF00090) Pfam (PF22195)	Homo sapiens (Human)	Complement factor P
3	E, G (A, G)	Complement C3	polymer	645	71393.3	2	UniProt (P01024) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703)	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
4	F, H (B, H)	Complement C3	polymer	915	104073.2	2	UniProt (P01024) Pfam (PF07677) Pfam (PF01759) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308)	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
5	I, J (J, L)	Complement factor B	polymer	505	57042.1	2	UniProt (P00751) Pfam (PF00092) Pfam (PF00089)	Homo sapiens (Human)	C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B
6	K, L (N, Q)	Inhibitor	polymer	85	9819.1	2	UniProt (A0A0H2DUF0) Pfam (PF11546) UniProt (by SIFTS) (Q931M7)	Staphylococcus aureus	Involved in expression of fibrinogen binding protein,phage associated,Staphylococcal complement inhibitor
7	M, N, P, Q (C, D, F, I)	beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose	branched		326.3	4	In PDB GlyTouCan (G36855WW)
8	O, R (E, K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
9	S, T, U, V, W... (M, O, P, R, S...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	8	In PDB GlyTouCan (G42666HT)
10	AA, BA, CA, DA, EA... (U, V, X, Y)	alpha-D-mannopyranose	non-polymer		180.2	18	Chemie (MAN)
11	SA, TA (B, H)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Sequence modifications

U, X: 28 - 255 (UniProt: P27918)

PDB	External Database	Details
Glu 256	-	expression tag
Asn 257	-	expression tag
Leu 258	-	expression tag
Tyr 259	-	expression tag
Phe 260	-	expression tag
Gln 261	-	expression tag

V, Y: 256 - 469 (UniProt: P27918)

PDB	External Database	Details
Gly 255	-	expression tag

J, L: 235 - 739 (UniProt: P00751)

PDB	External Database	Details
Gly 254	Asp 279	conflict
Ala 674	Ser 699	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	583503.4
Branched	Number of molecules	14
	Total formula weight	5841.5
Non-Polymers*	Number of molecules	20
	Total formula weight	3291.4
All*	Total formula weight	592636.3

*Water molecules are not included.