Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004866 | molecular_function | endopeptidase inhibitor activity |
B | 0004866 | molecular_function | endopeptidase inhibitor activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
G | 0004866 | molecular_function | endopeptidase inhibitor activity |
H | 0004866 | molecular_function | endopeptidase inhibitor activity |
H | 0005576 | cellular_component | extracellular region |
H | 0005615 | cellular_component | extracellular space |
J | 0004252 | molecular_function | serine-type endopeptidase activity |
J | 0005576 | cellular_component | extracellular region |
J | 0006508 | biological_process | proteolysis |
J | 0006956 | biological_process | complement activation |
L | 0004252 | molecular_function | serine-type endopeptidase activity |
L | 0005576 | cellular_component | extracellular region |
L | 0006508 | biological_process | proteolysis |
L | 0006956 | biological_process | complement activation |
N | 0005576 | cellular_component | extracellular region |
Q | 0005576 | cellular_component | extracellular region |
Functional Information from PROSITE/UniProt
site_id | PS00477 |
Number of Residues | 9 |
Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM |
Chain | Residue | Details |
B | PRO985-MET993 |
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
J | LEU497-CYS502 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Charge relay system |
Chain | Residue | Details |
J | HIS501 | |
X | TRP139 | |
X | TRP142 | |
X | TRP145 | |
X | TRP196 | |
X | TRP199 | |
J | ASP551 | |
J | ALA674 | |
L | HIS501 | |
L | ASP551 | |
L | ALA674 | |
U | TRP199 | |
X | TRP83 | |
X | TRP86 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754 |
Chain | Residue | Details |
J | ASN260 | |
L | ASN260 | |
H | ARG1281 | |
H | ARG1298 | |
G | SER16 | |
G | SER48 | |
G | SER275 | |
G | SER281 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911 |
Chain | Residue | Details |
J | LYS266 | |
L | LYS266 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
Chain | Residue | Details |
J | ASN353 | |
L | ASN353 | |
B | SER1551 | |
H | SER946 | |
H | SER1299 | |
H | SER1551 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150 |
Chain | Residue | Details |
B | ASN917 | |
H | ASN917 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
Chain | Residue | Details |
B | ASN1595 | |
H | ASN1595 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) |
Chain | Residue | Details |
B | CYS988 | |
B | GLN991 | |
H | CYS988 | |
H | GLN991 |