6RIJ
CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (Human) | Cyclin-A,Cyclin A |
| 3 | E, J (A, C) | 4-[[[5-nitroso-2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenol | non-polymer | 374.4 | 2 | Chemie (K4W) | |||
| 4 | F, G, K, M (A, B, C, D) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | H, I, L, N (B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127535.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1209.2 | |
| All* | Total formula weight | 128744.9 |
