6RFO

ERK2 MAP kinase with the activation loop of p38alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 14,Mitogen-activated protein kinase 1	polymer	372	42862.2	1	UniProt (P63086) UniProt (Q16539) Pfam (PF00069)	Rattus norvegicus (Norway Rat)	MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a,MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
2	B (A)	water	water		18.0	173	Chemie (HOH)

Sequence modifications

A: -7 - 158 (UniProt: P63086)

PDB	External Database	Details
Met -27	-	initiating methionine
Gly -26	-	expression tag
Ser -25	-	expression tag
Ser -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
Gly -15	-	expression tag
Leu -14	-	expression tag
Val -13	-	expression tag
Pro -12	-	expression tag
Arg -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
His -8	-	expression tag

A: 159 - 185 (UniProt: Q16539)

PDB	External Database	Details
Asp 160	Glu 163	conflict

A: 186 - 358 (UniProt: P63086)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42862.2
All*	Total formula weight	42862.2

*Water molecules are not included.