6RFK
Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Coagulation factor IX | polymer | 62 | 6841.8 | 1 | UniProt (P00740) Pfam (PF14670) | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 2 | B (S) | Coagulation factor IX | polymer | 235 | 26160.7 | 1 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 3 | C (I) | GLU-GLY-AR7-0QE | polymer | 4 | 395.9 | 1 | BIRD (PRD_000288) | synthetic construct | |
| 4 | D (E) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 5 | E (S) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | F, G, H, I, J... (S) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 7 | P, Q, R (E, S, I) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
E: 84 - 145 (UniProt: P00740)
S: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Met 84 | Leu 130 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gln 148 | Lys 362 | engineered mutation |
| Gln 150 | Arg 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33398.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1243.4 | |
| All* | Total formula weight | 34641.7 |
