6RFK

Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)

Functional Information from GO Data

Chain	GOid	namespace	contents
S	0004252	molecular_function	serine-type endopeptidase activity
S	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue B3P E 201

Chain	Residue
E	ASN92
E	HOH310
S	GLU204
S	GOL303
S	HOH402
S	HOH497
S	HOH591
E	ARG94
E	CYS95
E	GLU96
E	LYS122
E	SER123
E	HOH301
E	HOH308
E	HOH309

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA S 301

Chain	Residue
S	GLU70
S	ASN72
S	GLU75
S	GLU77
S	GLU80
S	GOL308

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL S 302

Chain	Residue
E	CYS88
E	CYS99
S	GLU127
S	TYR128
S	ILE129
S	ARG170
S	HOH467

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL S 303

Chain	Residue
E	B3P201
S	HIS185
S	GLU202
S	VAL203
S	GLU204
S	HOH402
S	HOH483
S	HOH486

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL S 304

Chain	Residue
S	GLY35
S	LYS37
S	VAL38
S	PHE41
S	CYS58
S	VAL62
S	LYS63

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL S 305

Chain	Residue
S	ASN97
S	TYR99
S	PHE174
S	THR175
S	TYR177
S	TRP215
S	HOH507

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL S 306

Chain	Residue
S	SER171
S	THR172
S	GLY216
S	GLU217
S	LYS224
S	TYR225

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL S 307

Chain	Residue
S	ASP21
S	LEU153
S	VAL154

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL S 308

Chain	Residue
S	GLU70
S	ASN72
S	ILE73
S	GLU75
S	GLU80
S	CA301
S	HOH489

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL S 309

Chain	Residue
S	HIS91
S	ASN93
S	HIS101
S	ARG233
S	HOH510

---

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL S 310

Chain	Residue
S	LYS126
S	ASN129
S	LYS230
S	SER232
S	ARG233
S	HOH405
S	HOH407
S	HOH546
S	HOH549

---

site_id	AD3
Number of Residues	6
Details	binding site for residue GOL S 311

Chain	Residue
S	LYS132
S	LEU162
S	ASP164
S	ASP164
S	HOH401
S	HOH401

---

site_id	AD4
Number of Residues	18
Details	binding site for residues AR7 I 3 and 0QE I 4

Chain	Residue
S	GLU219
S	CYS220
S	GLY226
S	HOH442
S	HOH499
I	GLU1
I	GLY2
I	HOH102
S	HIS57
S	ASP189
S	SER190
S	CYS191
S	GLN192
S	GLY193
S	SER195
S	SER214
S	TRP215
S	GLY216

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
S	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV

Chain	Residue	Details
S	ASP189-VAL200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CsCteGYrlaenqksC

Chain	Residue	Details
E	CYS109-CYS124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"EGF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	232
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"659613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"659613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10467148","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20080729","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121198","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RFN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10467148","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20080729","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121198","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---