6RBI

Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Lysine-specific demethylase 5B,Lysine-specific demethylase 5B	polymer	481	55457.6	1	UniProt (Q9UGL1) Pfam (PF02375) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928)	Homo sapiens (Human)	Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1
2	B, J (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	C (A)	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
4	D (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
5	E, G, H, I (A)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
6	F (A)	5-(1~{H}-1,2,3,4-tetrazol-5-yl)quinolin-8-ol	non-polymer		213.2	1	Chemie (JX8)
7	K, L (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
8	M (A)	water	water		18.0	126	Chemie (HOH)

Sequence modifications

A: 26 - 101 (UniProt: Q9UGL1)

PDB	External Database	Details
Ser 24	-	expression tag
Met 25	-	expression tag

A: 374 - 772 (UniProt: Q9UGL1)

PDB	External Database	Details
Gly 370	-	linker
Gly 371	-	linker
Gly 372	-	linker
Gly 373	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55457.6
Non-Polymers*	Number of molecules	11
	Total formula weight	788.2
All*	Total formula weight	56245.8

*Water molecules are not included.