6R6G
Structure of XBP1u-paused ribosome nascent chain complex with SRP.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | eS31 | polymer | 68 | 7986.4 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (Rabbit) | |
| 2 | B (1) | X-box-binding protein 1 | polymer | 24 | 2895.4 | 1 | UniProt (P17861) | Homo sapiens (Human) | XBP-1,Tax-responsive element-binding protein 5,TREB-5 |
| 3 | C (2) | P-tRNA | polymer | 75 | 24108.3 | 1 | Saccharomyces cerevisiae (Baker's yeast) | ||
| 4 | D (3) | E-tRNA | polymer | 75 | 24148.4 | 1 | Saccharomyces cerevisiae (Baker's yeast) | ||
| 5 | E (4) | mRNA | polymer | 6 | 1877.2 | 1 | Homo sapiens | ||
| 6 | F (5) | 28S ribosomal RNA | polymer | 3544 | 1148420.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 7 | G (6) | ribosomal protein RACK1 | polymer | 313 | 34669.1 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (Rabbit) | |
| 8 | H (7) | 5S ribosomal RNA | polymer | 120 | 38691.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 9 | I (8) | 5.8S ribosomal RNA | polymer | 151 | 48545.7 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 10 | J (9) | uS14 | polymer | 55 | 6559.6 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (Rabbit) | |
| 11 | K (A) | uL2 | polymer | 248 | 26998.6 | 1 | UniProt (G1TT27) Pfam (PF03947) Pfam (PF00181) | Oryctolagus cuniculus (Rabbit) | |
| 12 | L (AA) | 40S ribosomal protein S30 | polymer | 55 | 6317.5 | 1 | UniProt (G1T8A2) Pfam (PF04758) | Oryctolagus cuniculus (Rabbit) | |
| 13 | M (B) | uL3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (Rabbit) | |
| 14 | N (BB) | 40S ribosomal protein S7 | polymer | 189 | 21629.3 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (Rabbit) | |
| 15 | O (C) | uL4 | polymer | 362 | 41101.4 | 1 | UniProt (G1SVW5) Pfam (PF00573) Pfam (PF14374) | Oryctolagus cuniculus (Rabbit) | |
| 16 | P (CC) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (Rabbit) | |
| 17 | Q (DD) | Ribosomal protein S9 (Predicted) | polymer | 185 | 21649.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (Rabbit) | |
| 18 | R (D) | 60S ribosomal protein L5 | polymer | 293 | 34077.4 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) | Oryctolagus cuniculus (Rabbit) | |
| 19 | S (EE) | Ribosomal protein S11 | polymer | 151 | 17586.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (Rabbit) | |
| 20 | T (E) | 60S ribosomal protein L6 | polymer | 251 | 28818.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (Rabbit) | |
| 21 | U (FF) | Ribosomal protein S28 | polymer | 62 | 7007.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (Rabbit) | |
| 22 | V (F) | uL30 | polymer | 225 | 26658.8 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) | Oryctolagus cuniculus (Rabbit) | |
| 23 | W (GG) | Ribosomal protein S20 | polymer | 100 | 11395.5 | 1 | Oryctolagus cuniculus (Rabbit) | uS10 | |
| 24 | X (G) | eL8 | polymer | 240 | 27351.4 | 1 | UniProt (G1STW0) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 25 | Y (H) | uL6 | polymer | 190 | 21627.2 | 1 | UniProt (G1TX33) Pfam (PF00347) UniProt (by SIFTS) (G1SWI6) | Oryctolagus cuniculus (Rabbit) | |
| 26 | Z (HH) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 1 | Oryctolagus cuniculus (Rabbit) | eS21 | |
| 27 | AA (I) | Ribosomal protein L10 (Predicted) | polymer | 213 | 24511.9 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (Rabbit) | |
| 28 | BA (II) | uS13 | polymer | 144 | 16898.6 | 1 | UniProt (G1SZI5) Pfam (PF00416) UniProt (by SIFTS) (G1TPG3) | Oryctolagus cuniculus (Rabbit) | |
| 29 | CA (JJ) | 40S ribosomal protein S27 | polymer | 83 | 9349.0 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (Rabbit) | |
| 30 | DA (J) | Ribosomal protein L11 | polymer | 170 | 19399.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) | Oryctolagus cuniculus (Rabbit) | |
| 31 | EA (K) | 18S ribosomal RNA | polymer | 1698 | 548040.2 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 32 | FA (KK) | eS17 | polymer | 132 | 15250.7 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (Rabbit) | |
| 33 | GA (L) | 60S ribosomal protein L13 | polymer | 210 | 24200.5 | 1 | UniProt (G1TPV0) | Oryctolagus cuniculus (Rabbit) | |
| 34 | HA (LL) | 40S ribosomal protein S26 | polymer | 101 | 11645.8 | 1 | Oryctolagus cuniculus (Rabbit) | eS26 | |
| 35 | IA (M) | Ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (U3KNW6) Pfam (PF01929) UniProt (by SIFTS) (G1SZ12) | Oryctolagus cuniculus (Rabbit) | |
| 36 | JA (MM) | 40S ribosomal protein S14 | polymer | 136 | 14544.7 | 1 | Oryctolagus cuniculus (Rabbit) | uS11 | |
| 37 | KA (N) | Ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (Rabbit) | |
| 38 | LA (NN) | 40S ribosomal protein S24 | polymer | 124 | 14432.1 | 1 | Oryctolagus cuniculus (Rabbit) | eS24 | |
| 39 | MA (O) | 60S ribosomal protein L13a | polymer | 199 | 23144.9 | 1 | Oryctolagus cuniculus (Rabbit) | uL13 | |
| 40 | NA (OO) | ribosomal protein eS25 | polymer | 75 | 8526.1 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (Rabbit) | |
| 41 | OA (P) | uL22 | polymer | 153 | 17758.7 | 1 | UniProt (G1TVT6) Pfam (PF00237) UniProt (by SIFTS) (G1SCJ6) | Oryctolagus cuniculus (Rabbit) | |
| 42 | PA (PP) | eS19 | polymer | 141 | 15611.0 | 1 | UniProt (G1TN62) Pfam (PF01090) | Oryctolagus cuniculus (Rabbit) | |
| 43 | QA (Q) | eL18 | polymer | 187 | 21568.5 | 1 | UniProt (G1TX70) Pfam (PF17135) | Oryctolagus cuniculus (Rabbit) | |
| 44 | RA (QQ) | ribosomal protein uS15 | polymer | 149 | 17057.1 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (Rabbit) | |
| 45 | SA (R) | 60S ribosomal protein L19 | polymer | 180 | 21613.0 | 1 | Oryctolagus cuniculus (Rabbit) | eL19 | |
| 46 | TA (RR) | 40S ribosomal protein S12 | polymer | 117 | 13048.2 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 47 | UA (S) | eL20 | polymer | 176 | 20827.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 48 | VA (SS) | eS10 | polymer | 96 | 11529.7 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (Rabbit) | |
| 49 | WA (T) | eL21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (Rabbit) | |
| 50 | XA (TT) | Ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (Rabbit) | |
| 51 | YA (UU) | Ribosomal protein S16 | polymer | 142 | 16032.8 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (Rabbit) | |
| 52 | ZA (U) | 60S ribosomal protein L22 | polymer | 99 | 11495.3 | 1 | Oryctolagus cuniculus (Rabbit) | eL22 | |
| 53 | AB (VV) | Ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (Rabbit) | |
| 54 | BB (V) | eL14 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (Rabbit) | |
| 55 | CB (W) | Ribosomal protein L24 | polymer | 121 | 14131.5 | 1 | UniProt (G1SE28) Pfam (PF01246) | Oryctolagus cuniculus (Rabbit) | |
| 56 | DB (WW) | uS19 | polymer | 120 | 14246.9 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (Rabbit) | |
| 57 | EB (X) | uL23 | polymer | 118 | 13727.2 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) | Oryctolagus cuniculus (Rabbit) | |
| 58 | FB (Y) | Ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (Rabbit) | |
| 59 | GB (Z) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (Rabbit) | |
| 60 | HB (a) | uL15 | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) | Oryctolagus cuniculus (Rabbit) | |
| 61 | IB (b) | eL29 | polymer | 116 | 13401.0 | 1 | UniProt (G1SGR6) Pfam (PF01779) | Oryctolagus cuniculus (Rabbit) | |
| 62 | JB (c) | eL30 | polymer | 98 | 10914.8 | 1 | UniProt (G1TDL2) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 63 | KB (d) | eL31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (Rabbit) | |
| 64 | LB (e) | eL32 | polymer | 128 | 15022.0 | 1 | UniProt (G1TUN8) Pfam (PF01655) | Oryctolagus cuniculus (Rabbit) | |
| 65 | MB (f) | eL33 | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (Rabbit) | |
| 66 | NB (g) | eL34 | polymer | 114 | 12994.6 | 1 | UniProt (G1U945) Pfam (PF01199) UniProt (by SIFTS) (G1TXG5) | Oryctolagus cuniculus (Rabbit) | |
| 67 | OB (h) | uL29 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (Rabbit) | |
| 68 | PB (i) | 60S ribosomal protein L36 | polymer | 102 | 11888.4 | 1 | UniProt (G1TTQ5) Pfam (PF01158) | Oryctolagus cuniculus (Rabbit) | |
| 69 | QB (j) | Ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (Rabbit) | |
| 70 | RB (k) | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 1 | Oryctolagus cuniculus (Rabbit) | eL38 | |
| 71 | SB (l) | eL39 | polymer | 50 | 6324.6 | 1 | UniProt (G1TTN1) Pfam (PF00832) | Oryctolagus cuniculus (Rabbit) | |
| 72 | TB (m) | 60S ribosomal protein L40 | polymer | 52 | 6199.6 | 1 | Oryctolagus cuniculus (Rabbit) | eL40 | |
| 73 | UB (n) | 60s ribosomal protein l41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (Rabbit) | eL41 |
| 74 | VB (o) | eL42 | polymer | 104 | 12198.6 | 1 | UniProt (G1T040) Pfam (PF00935) | Oryctolagus cuniculus (Rabbit) | |
| 75 | WB (p) | ribosomal protein eL43 | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (Rabbit) | |
| 76 | XB (q) | uS2 | polymer | 217 | 24361.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 77 | YB (r) | eL28 | polymer | 124 | 14220.7 | 1 | UniProt (G1U7L1) Pfam (PF01778) | Oryctolagus cuniculus (Rabbit) | |
| 78 | ZB (s) | 60S acidic ribosomal protein P0 | polymer | 196 | 21521.1 | 1 | UniProt (G1U6N2) | Oryctolagus cuniculus (Rabbit) | |
| 79 | AC (t) | uL11 | polymer | 153 | 16561.1 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) | Oryctolagus cuniculus (Rabbit) | |
| 80 | BC (u) | 40S ribosomal protein S3a | polymer | 213 | 24759.1 | 1 | UniProt (G1SS70) Pfam (PF01015) | Oryctolagus cuniculus (Rabbit) | |
| 81 | CC (v) | uS5 | polymer | 221 | 24441.8 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 82 | DC (w) | Ribosomal protein S3 | polymer | 228 | 25215.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (Rabbit) | |
| 83 | EC (x) | 40S ribosomal protein S4 | polymer | 262 | 29523.7 | 1 | UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Oryctolagus cuniculus (Rabbit) | |
| 84 | FC (y) | Ribosomal protein S5 | polymer | 191 | 21525.9 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (Rabbit) | |
| 85 | GC (z) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (Rabbit) | |
| 86 | HC (AB) | Signal recognition particle 54 kDa protein | polymer | 431 | 47844.2 | 1 | UniProt (P61010) Pfam (PF02881) Pfam (PF00448) Pfam (PF02978) | Canis lupus familiaris (Dog) | SRP54 |
| 87 | IC (AF) | 7S RNA | polymer | 206 | 66779.7 | 1 | Canis lupus familiaris (Dog) | ||
| 88 | JC (AC) | Signal recognition particle subunit SRP19 | polymer | 105 | 12159.2 | 1 | UniProt (J9PAS6) Pfam (PF01922) | Canis lupus familiaris (Dog) | |
| 89 | KC (AI) | Signal recognition particle subunit SRP68 | polymer | 195 | 23220.7 | 1 | UniProt (Q00004) Pfam (PF16969) | Canis lupus familiaris (Dog) | SRP68,Signal recognition particle 68 kDa protein |
| 90 | LC (AD) | Signal recognition particle 9 kDa protein | polymer | 74 | 8705.1 | 1 | UniProt (F1Q0Z5) | Canis lupus familiaris (Dog) | SRP9 |
| 91 | MC (AE) | Signal recognition particle 14 kDa protein | polymer | 94 | 10651.4 | 1 | UniProt (P16255) Pfam (PF02290) | Canis lupus familiaris (Dog) | SRP14 |
| 92 | NC (AG) | Signal sequence (HR2) | polymer | 12 | 1375.9 | 1 | Homo sapiens (Human) | ||
| 93 | AD, AE, AF, AG, AH... (5, K, j, 7, 8...) | MAGNESIUM ION | non-polymer | 24.3 | 299 | Chemie (MG) | |||
| 94 | AO, BO, DO, EO, FO (g, j, m, o, p) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
1: 237 - 260 (UniProt: P17861)
CC: 2 - 207 (UniProt: G1TJW1)
G: 80 - 319 (UniProt: G1STW0)
L: 2 - 211 (UniProt: G1TPV0)
PP: 3 - 143 (UniProt: G1TN62)
Q: 2 - 188 (UniProt: G1TX70)
x: 2 - 263 (UniProt: G1TK17)
AD: 2 - 75 (UniProt: F1Q0Z5)
AE: 2 - 95 (UniProt: P16255)
| PDB | External Database | Details |
|---|---|---|
| Ala 255 | Ser 255 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | Cys 167 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 47 | - | insertion |
| Pro 48 | - | insertion |
| Arg 49 | - | insertion |
| Pro 50 | - | insertion |
| Ala 51 | - | insertion |
| Ala 52 | - | insertion |
| Gly 53 | - | insertion |
| Pro 54 | - | insertion |
| Ile 55 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | Trp 119 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 6 | Leu 6 | conflict |
| Arg 14 | Trp 14 | conflict |
| Ile 23 | Met 23 | conflict |
| Tyr 24 | Cys 24 | conflict |
| Arg 38 | His 38 | conflict |
| Asn 57 | Lys 57 | conflict |
| Met 66 | Val 66 | conflict |
| Gly 74 | Asp 74 | conflict |
| Arg 75 | Pro 75 | conflict |
| Val 86 | Ile 86 | conflict |
| Arg 110 | His 110 | conflict |
| Gly 117 | Glu 117 | conflict |
| Asp 124 | His 124 | conflict |
| Arg 150 | Gln 150 | conflict |
| Arg 172 | Gly 172 | conflict |
| Arg 184 | Trp 184 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | Ser 25 | conflict |
| Arg 51 | Lys 51 | conflict |
| Thr 78 | Ala 78 | conflict |
| Val 156 | Met 156 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 37 | Ser 37 | conflict |
| Val 40 | Ile 40 | conflict |
| Lys 52 | Arg 52 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 22 | Leu 22 | conflict |
| Tyr 27 | Phe 27 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 92 |
| Total formula weight | 3358794.4 | |
| Non-Polymers* | Number of molecules | 304 |
| Total formula weight | 7594.2 | |
| All* | Total formula weight | 3366388.7 |
