6R4U
Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, E) | DNA primase small subunit | polymer | 410 | 48720.5 | 2 | UniProt (P49642) Pfam (PF01896) | Homo sapiens (Human) | DNA primase 49 kDa subunit,p49 |
| 2 | C, G (A, E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, H, I (A, E) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 4 | F, J (A, E) | 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine | non-polymer | 525.2 | 2 | Chemie (HFD) | |||
| 5 | K (E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | L, M (A, E) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, E: 1 - 407 (UniProt: P49642)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97441.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1463.0 | |
| All* | Total formula weight | 98904.0 |
