6R4U

Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005658	cellular_component	alpha DNA polymerase:primase complex
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0032553	molecular_function	ribonucleotide binding
A	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005658	cellular_component	alpha DNA polymerase:primase complex
E	0006260	biological_process	DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0008270	molecular_function	zinc ion binding
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0032553	molecular_function	ribonucleotide binding
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS121
A	CYS122
A	CYS128
A	CYS131

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 502

Chain	Residue
A	ASP109
A	ASP111
A	MN503
A	HFD504
A	HOH635

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MN A 503

Chain	Residue
A	ASP109
A	ASP111
A	ASP306
A	MN502
A	HFD504
A	HOH662

---

site_id	AC4
Number of Residues	19
Details	binding site for residue HFD A 504

Chain	Residue
A	LYS77
A	ASP79
A	ASP109
A	ASP111
A	SER160
A	ARG162
A	ARG163
A	HIS166
A	HIS315
A	LEU316
A	LEU317
A	LYS318
A	HIS324
A	MN502
A	MN503
A	HOH626
A	HOH635
A	HOH661
A	HOH664

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS121
E	CYS122
E	CYS128
E	CYS131

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MN E 502

Chain	Residue
E	ASP109
E	ASP111
E	MN503
E	HFD504
E	HOH629

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN E 503

Chain	Residue
E	ASP109
E	ASP111
E	ASP306
E	MN502
E	HFD504
E	HOH638

---

site_id	AC8
Number of Residues	19
Details	binding site for residue HFD E 504

Chain	Residue
E	TYR54
E	ARG56
E	LYS77
E	ASP79
E	ASP109
E	ASP111
E	SER160
E	ARG162
E	ARG163
E	HIS166
E	HIS315
E	LEU316
E	LEU317
E	LYS318
E	HIS324
E	MN502
E	MN503
E	HOH615
E	HOH629

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO E 505

Chain	Residue
E	LEU204
E	SER205
E	GLU206
E	ASN281
E	TRP291

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"Zinc knuckle motif","evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6R4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24239947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---