6R4J
Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | polymer | 687 | 77768.1 | 2 | UniProt (Q06210) Pfam (PF13522) Pfam (PF01380) | Homo sapiens (Human) | D-fructose-6-phosphate amidotransferase 1,Glutamine:fructose-6-phosphate amidotransferase 1,GFAT1,Hexosephosphate aminotransferase 1 |
| 2 | C, G (A, B) | URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | non-polymer | 607.4 | 2 | Chemie (UD1) | |||
| 3 | D, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 4 | E, I (A, B) | GLUCOSE-6-PHOSPHATE | non-polymer | 260.1 | 2 | Chemie (G6Q) PubChem (20831679) PubChem (99058) PubChem (3034788) PubChem (3034794) PubChem (18603327) PubChem (25323050) PubChem (439958) PubChem (44229174) PubChem (51404088) PubChem (51404090) PubChem (5459942) PubChem (5460110) PubChem (6101690) PubChem (87305227) PubChem (87891597) PubChem (88507758) PubChem (88508138) PubChem (85187) PubChem (13179156) PubChem (13179157) | |||
| 5 | F (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 681 (UniProt: Q06210)
| PDB | External Database | Details |
|---|---|---|
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| Glu 451 | Gly 451 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 155536.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1930.7 | |
| All* | Total formula weight | 157466.9 |
