6R4J

Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	polymer	687	77768.1	2	UniProt (Q06210) Pfam (PF13522) Pfam (PF01380) In PDB	Homo sapiens (Human)	D-fructose-6-phosphate amidotransferase 1,Glutamine:fructose-6-phosphate amidotransferase 1,GFAT1,Hexosephosphate aminotransferase 1
2	A, B	URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE	non-polymer		607.4	2	Chemie (UD1)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	GLUCOSE-6-PHOSPHATE	non-polymer		260.1	2	Chemie (G6Q)
5	A	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
6		water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B: 1 - 681 (UniProt: Q06210)

PDB	External Database	Details
His 299	-	insertion
His 299	-	insertion
His 299	-	insertion
His 299	-	insertion
His 299	-	insertion
His 299	-	insertion
Glu 451	Gly 451	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	155536.1
Non-Polymers*	Number of molecules	7
	Total formula weight	1930.7
All*	Total formula weight	157466.9

*Water molecules are not included.