6R4J
Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | polymer | 687 | 77768.1 | 2 | UniProt (Q06210) Pfam (PF13522) Pfam (PF01380) | Homo sapiens (Human) | D-fructose-6-phosphate amidotransferase 1,Glutamine:fructose-6-phosphate amidotransferase 1,GFAT1,Hexosephosphate aminotransferase 1 |
| 2 | C, G (A, B) | URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | non-polymer | 607.4 | 2 | Chemie (UD1) | |||
| 3 | D, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, I (A, B) | GLUCOSE-6-PHOSPHATE | non-polymer | 260.1 | 2 | Chemie (G6Q) | |||
| 5 | F (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 681 (UniProt: Q06210)
| PDB | External Database | Details |
|---|---|---|
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| His 299 | - | insertion |
| Glu 451 | Gly 451 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 155536.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1930.7 | |
| All* | Total formula weight | 157466.9 |
