6R4J
Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004360 | molecular_function | glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| A | 1901137 | biological_process | carbohydrate derivative biosynthetic process |
| B | 0004360 | molecular_function | glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 1901137 | biological_process | carbohydrate derivative biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue UD1 A 701 |
| Chain | Residue |
| A | GLN310 |
| A | GLY461 |
| A | VAL462 |
| A | HIS463 |
| A | MG702 |
| A | HOH851 |
| B | TYR535 |
| B | HIS536 |
| A | ARG343 |
| A | GLY354 |
| A | GLY355 |
| A | GLY445 |
| A | THR447 |
| A | SER455 |
| A | THR458 |
| A | CYS460 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | SER455 |
| A | ARG456 |
| A | THR458 |
| A | UD1701 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue G6Q A 703 |
| Chain | Residue |
| A | GLY375 |
| A | THR376 |
| A | SER377 |
| A | SER421 |
| A | GLN422 |
| A | SER423 |
| A | THR426 |
| A | SER474 |
| A | LYS558 |
| A | GLU561 |
| A | HOH804 |
| A | HOH821 |
| A | HOH878 |
| B | HIS577 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue GLU A 704 |
| Chain | Residue |
| A | CYS2 |
| A | HIS93 |
| A | ARG95 |
| A | TRP96 |
| A | THR98 |
| A | HIS99 |
| A | HIS108 |
| A | HIS122 |
| A | GLY124 |
| A | ASP148 |
| A | THR149 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue UD1 B 701 |
| Chain | Residue |
| B | ARG343 |
| B | GLY354 |
| B | GLY355 |
| B | GLY445 |
| B | THR447 |
| B | SER455 |
| B | THR458 |
| B | CYS460 |
| B | GLY461 |
| B | VAL462 |
| B | HIS463 |
| B | MG702 |
| B | HOH822 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 702 |
| Chain | Residue |
| B | SER455 |
| B | ARG456 |
| B | THR458 |
| B | UD1701 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue G6Q B 703 |
| Chain | Residue |
| A | HIS577 |
| B | GLY375 |
| B | THR376 |
| B | SER377 |
| B | SER421 |
| B | GLN422 |
| B | SER423 |
| B | THR426 |
| B | ALA473 |
| B | SER474 |
| B | LYS558 |
| B | GLU561 |
| B | HOH801 |
| B | HOH803 |
| B | HOH813 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 278 |
| Details | Domain: {"description":"SIS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 282 |
| Details | Domain: {"description":"SIS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For GATase activity","evidences":[{"source":"UniProtKB","id":"P14742","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19059404","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZJ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
