6QYX

p38(alpha) MAP kinase with the activation loop of ERK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 14,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 14	polymer	366	41982.9	1	UniProt (Q16539) UniProt (D2CIU1) Pfam (PF00069)	Homo sapiens (Human)	MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
2	B (A)	octyl beta-D-glucopyranoside	non-polymer		292.4	1	Chemie (BOG)
3	C (A)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
4	D (A)	water	water		18.0	204	Chemie (HOH)

Sequence modifications

A: 1 - 172 (UniProt: Q16539)

PDB	External Database	Details
Cys 167	Leu 167	conflict

A: 173 - 189 (UniProt: D2CIU1)
A: 190 - 366 (UniProt: Q16539)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	41982.9
Non-Polymers*	Number of molecules	2
	Total formula weight	530.7
All*	Total formula weight	42513.5

*Water molecules are not included.