6QH6
AP2 clathrin adaptor core with two cargo peptides in open+ conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AP-2 complex subunit alpha | polymer | 621 | 69642.3 | 1 | UniProt (Q66HM2) Pfam (PF01602) UniProt (by SIFTS) (P18484) | Rattus norvegicus (Norway rat) | |
| 2 | B (B) | AP-2 complex subunit beta | polymer | 592 | 67091.3 | 1 | UniProt (P63010) Pfam (PF01602) | Homo sapiens (human) | AP105B,Adaptor protein complex AP-2 subunit beta,Adaptor-related protein complex 2 subunit beta,Beta-2-adaptin,Beta-adaptin,Clathrin assembly protein complex 2 beta large chain,Plasma membrane adaptor HA2/AP2 adaptin beta subunit |
| 3 | C (M) | AP-2 complex subunit mu | polymer | 446 | 51124.1 | 1 | UniProt (Q3ZC13) Pfam (PF01217) Pfam (PF00928) | Bos taurus (cattle) | AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,HA2 50 kDa subunit,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein |
| 4 | D (N) | AP-2 complex subunit mu | polymer | 446 | 51044.1 | 1 | UniProt (P84092) Pfam (PF01217) Pfam (PF00928) | Rattus norvegicus (Norway rat) | AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein |
| 5 | E (P) | TGN38 CARGO PEPTIDE | polymer | 6 | 808.9 | 1 | Homo sapiens | ||
| 6 | F (Q) | CD4 CARGO PEPTIDE | polymer | 10 | 1314.5 | 1 | UniProt (by SIFTS) (P01730) | Homo sapiens | |
| 7 | G (S) | AP-2 complex subunit sigma | polymer | 142 | 17038.7 | 1 | UniProt (P62743) Pfam (PF01217) | Mus musculus (house mouse) | Adaptor protein complex AP-2 subunit sigma,Adaptor-related protein complex 2 subunit sigma,Clathrin assembly protein 2 sigma small chain,Clathrin coat assembly protein AP17,Clathrin coat-associated protein AP17,Plasma membrane adaptor AP-2 17 kDa protein,Sigma-adaptin 3b,Sigma2-adaptin |
Sequence modifications
A: 1 - 621 (UniProt: Q66HM2)
M: 1 - 446 (UniProt: Q3ZC13)
N: 1 - 446 (UniProt: P84092)
| PDB | External Database | Details |
|---|---|---|
| Asp 8 | Glu 8 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 237 | - | insertion |
| Glu 238 | - | insertion |
| Gln 239 | - | insertion |
| Lys 240 | - | insertion |
| Leu 241 | - | insertion |
| Ile 242 | - | insertion |
| Ser 243 | - | insertion |
| Glu 244 | - | insertion |
| Glu 245 | - | insertion |
| Asp 246 | - | insertion |
| Leu 247 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Met 237 | - | insertion |
| Glu 238 | - | insertion |
| Gln 239 | - | insertion |
| Lys 240 | - | insertion |
| Leu 241 | - | insertion |
| Ile 242 | - | insertion |
| Ser 243 | - | insertion |
| Glu 244 | - | insertion |
| Glu 245 | - | insertion |
| Asp 246 | - | insertion |
| Leu 247 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 258063.9 | |
| All* | Total formula weight | 258063.9 |
