6QH6

AP2 clathrin adaptor core with two cargo peptides in open+ conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
M	0006886	biological_process	intracellular protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030131	cellular_component	clathrin adaptor complex
N	0006886	biological_process	intracellular protein transport
N	0016192	biological_process	vesicle-mediated transport
N	0030131	cellular_component	clathrin adaptor complex
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005886	cellular_component	plasma membrane
S	0005905	cellular_component	clathrin-coated pit
S	0006886	biological_process	intracellular protein transport
S	0006897	biological_process	endocytosis
S	0009898	cellular_component	cytoplasmic side of plasma membrane
S	0015031	biological_process	protein transport
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030122	cellular_component	AP-2 adaptor complex
S	0035615	molecular_function	clathrin adaptor activity
S	0045202	cellular_component	synapse
S	0048488	biological_process	synaptic vesicle endocytosis
S	0071944	cellular_component	cell periphery
S	0072583	biological_process	clathrin-dependent endocytosis
S	0098793	cellular_component	presynapse
S	0098794	cellular_component	postsynapse
S	0098884	biological_process	postsynaptic neurotransmitter receptor internalization

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF

Chain	Residue	Details
S	ILE57-PHE67

---

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE

Chain	Residue	Details
N	ILE159-GLU179
M	ILE159-GLU179

---

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY

Chain	Residue	Details
N	ILE274-TYR288
M	ILE274-TYR288

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:2105883

Chain	Residue	Details
Q	SEP3
Q	SER10
A	TYR53
A	LYS57

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96CW1

Chain	Residue	Details
N	SER45

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q96CW1

Chain	Residue	Details
N	THR156

---