6Q9W
X-ray structure of compound 15 bound to HdmX: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein Mdm4 | polymer | 100 | 11187.0 | 2 | UniProt (O15151) | Homo sapiens (Human) | Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4 |
| 2 | C, G (A, B) | (4~{S})-4-(4-chlorophenyl)-5-[(1~{S})-1-(3-chlorophenyl)ethyl]-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one | non-polymer | 552.5 | 2 | Chemie (HRT) | |||
| 3 | D, H (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, I, J (A, B) | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 4 | Chemie (O4B) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A, B: 15 - 112 (UniProt: O15151)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Ser 18 | Cys 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22374.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2354.3 | |
| All* | Total formula weight | 24728.3 |
