6Q6C
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Kunitz-type conkunitzin-S1 | polymer | 61 | 6973.7 | 2 | UniProt (P0C1X2) Pfam (PF00014) In PDB | Conus striatus (Striated cone) | Conk-S1 |
2 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
3 | A, B | NITRATE ION | non-polymer | 62.0 | 6 | Chemie (NO3) | |||
4 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
5 | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 60 (UniProt: P0C1X2)
PDB | External Database | Details |
---|---|---|
Asp 55 | Arg 81 | engineered mutation |
Ala 61 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 13947.3 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 624.0 | |
All* | Total formula weight | 14571.4 |