6Q6C
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kunitz-type conkunitzin-S1 | polymer | 61 | 6973.7 | 2 | UniProt (P0C1X2) Pfam (PF00014) | Conus striatus (Striated cone) | Conk-S1 |
| 2 | C, J (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | D, E, F, G, H... (A, B) | NITRATE ION | non-polymer | 62.0 | 6 | Chemie (NO3) | |||
| 4 | I (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 60 (UniProt: P0C1X2)
| PDB | External Database | Details |
|---|---|---|
| Asp 55 | Arg 81 | engineered mutation |
| Ala 61 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13947.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 624.0 | |
| All* | Total formula weight | 14571.4 |
