6Q6C
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0015459 | molecular_function | potassium channel regulator activity |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
| B | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 101 |
| Chain | Residue |
| A | LYS18 |
| B | ASP52 |
| A | GLU20 |
| A | ARG22 |
| A | ARG48 |
| A | HOH207 |
| A | HOH208 |
| B | PHE47 |
| B | ARG48 |
| B | ARG49 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NO3 A 102 |
| Chain | Residue |
| A | PHE47 |
| A | ARG48 |
| A | ARG49 |
| A | ASP52 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NO3 A 103 |
| Chain | Residue |
| A | ARG22 |
| A | TYR37 |
| A | GLY39 |
| A | ASN46 |
| A | HOH208 |
| A | HOH212 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue NO3 A 104 |
| Chain | Residue |
| A | ARG48 |
| A | HOH204 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue NO3 A 106 |
| Chain | Residue |
| B | SER5 |
| B | ASP8 |
| B | ARG49 |
| B | TYR51 |
| B | NO3103 |
| B | HOH228 |
| B | HOH255 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 101 |
| Chain | Residue |
| A | PRO10 |
| A | ALA11 |
| A | ASN26 |
| A | HOH221 |
| B | ALA11 |
| B | ASP12 |
| B | SER13 |
| B | HOH215 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 102 |
| Chain | Residue |
| B | SER5 |
| B | ARG49 |
| B | THR50 |
| B | TYR51 |
| B | HOH201 |
| B | HOH224 |
| B | HOH243 |
| B | HOH246 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue NO3 B 103 |
| Chain | Residue |
| A | ARG48 |
| A | ARG49 |
| A | NO3106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Domain: {"description":"BPTI/Kunitz inhibitor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Threonine amide","evidences":[{"source":"PubMed","id":"15833744","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
