6Q0R
Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA damage-binding protein 1 | polymer | 864 | 96425.6 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
2 | B | DDB1- and CUL4-associated factor 15 | polymer | 276 | 31611.0 | 1 | UniProt (Q66K64) Pfam (PF14939) In PDB | Homo sapiens (Human) | |
3 | C | DDB1- and CUL4-associated factor 15 | polymer | 263 | 29893.5 | 1 | UniProt (Q66K64) In PDB | Homo sapiens (Human) | |
4 | D | RNA-binding protein 39 | polymer | 107 | 12062.6 | 1 | UniProt (Q14498) Pfam (PF00076) In PDB | Homo sapiens (Human) | CAPER alpha,Hepatocellular carcinoma protein 1,RNA-binding motif protein 39,RNA-binding region-containing protein 2,Splicing factor HCC1 |
5 | E | DET1- and DDB1-associated protein 1 | polymer | 126 | 14542.2 | 1 | UniProt (Q9BW61) Pfam (PF10172) In PDB | Homo sapiens (Human) | Placenta cross-immune reaction antigen 1,PCIA-1 |
6 | B | OXAMIC ACID | non-polymer | 89.0 | 1 | Chemie (OXM) | |||
7 | B | 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide | non-polymer | 336.4 | 1 | Chemie (O6M) | |||
8 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
9 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 1 - 699 (UniProt: Q16531)
A: 706 - 1140 (UniProt: Q16531)
B: 34 - 260 (UniProt: Q66K64)
C: 383 - 600 (UniProt: Q66K64)
D: 250 - 332 (UniProt: Q14498)
E: 1 - 102 (UniProt: Q9BW61)
PDB | External Database | Details |
---|---|---|
Met -27 | - | initiating methionine |
Gly -26 | - | expression tag |
Ser -25 | - | expression tag |
Ser -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
Ser -17 | - | expression tag |
Ala -16 | - | expression tag |
Ala -15 | - | expression tag |
His -14 | - | expression tag |
Ile -13 | - | expression tag |
Val -12 | - | expression tag |
Met -11 | - | expression tag |
Val -10 | - | expression tag |
Asp -9 | - | expression tag |
Ala -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Pro -5 | - | expression tag |
Thr -4 | - | expression tag |
Lys -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 700 | - | linker |
Asn 701 | - | linker |
Gly 702 | - | linker |
Asn 703 | - | linker |
Ser 704 | - | linker |
Gly 705 | - | linker |
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
Asp -14 | - | expression tag |
Trp -13 | - | expression tag |
Ser -12 | - | expression tag |
His -11 | - | expression tag |
Pro -10 | - | expression tag |
Gln -9 | - | expression tag |
Phe -8 | - | expression tag |
Glu -7 | - | expression tag |
Lys -6 | - | expression tag |
Ser -5 | - | expression tag |
Ala -4 | - | expression tag |
Val -3 | - | expression tag |
Gly -2 | - | expression tag |
Leu -1 | - | expression tag |
Asn 0 | - | expression tag |
Asp 1 | - | expression tag |
Ile 2 | - | expression tag |
Phe 3 | - | expression tag |
Glu 4 | - | expression tag |
Ala 5 | - | expression tag |
Gln 6 | - | expression tag |
Lys 7 | - | expression tag |
Ile 8 | - | expression tag |
Glu 9 | - | expression tag |
Trp 10 | - | expression tag |
His 11 | - | expression tag |
Glu 12 | - | expression tag |
Gly 13 | - | expression tag |
Gly 14 | - | expression tag |
Gly 15 | - | expression tag |
Gly 16 | - | expression tag |
Ser 17 | - | expression tag |
Gly 18 | - | expression tag |
Glu 19 | - | expression tag |
Asn 20 | - | expression tag |
Leu 21 | - | expression tag |
Tyr 22 | - | expression tag |
Phe 23 | - | expression tag |
Gln 24 | - | expression tag |
Gly 25 | - | expression tag |
Gly 26 | - | expression tag |
Gly 27 | - | expression tag |
Arg 28 | - | expression tag |
Met 29 | - | expression tag |
Gly 30 | - | expression tag |
Arg 31 | - | expression tag |
Arg 32 | - | expression tag |
Arg 33 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 338 | - | initiating methionine |
Asp 339 | - | expression tag |
Trp 340 | - | expression tag |
Ser 341 | - | expression tag |
His 342 | - | expression tag |
Pro 343 | - | expression tag |
Gln 344 | - | expression tag |
Phe 345 | - | expression tag |
Glu 346 | - | expression tag |
Lys 347 | - | expression tag |
Ser 348 | - | expression tag |
Ala 349 | - | expression tag |
Val 350 | - | expression tag |
Gly 351 | - | expression tag |
Leu 352 | - | expression tag |
Asn 353 | - | expression tag |
Asp 354 | - | expression tag |
Ile 355 | - | expression tag |
Phe 356 | - | expression tag |
Glu 357 | - | expression tag |
Ala 358 | - | expression tag |
Gln 359 | - | expression tag |
Lys 360 | - | expression tag |
Ile 361 | - | expression tag |
Glu 362 | - | expression tag |
Trp 363 | - | expression tag |
His 364 | - | expression tag |
Glu 365 | - | expression tag |
Gly 366 | - | expression tag |
Gly 367 | - | expression tag |
Gly 368 | - | expression tag |
Gly 369 | - | expression tag |
Ser 370 | - | expression tag |
Gly 371 | - | expression tag |
Glu 372 | - | expression tag |
Asn 373 | - | expression tag |
Leu 374 | - | expression tag |
Tyr 375 | - | expression tag |
Phe 376 | - | expression tag |
Gln 377 | - | expression tag |
Gly 378 | - | expression tag |
Gly 379 | - | expression tag |
Gly 380 | - | expression tag |
Arg 381 | - | expression tag |
Met 382 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 226 | - | initiating methionine |
Gly 227 | - | expression tag |
Ser 228 | - | expression tag |
Ser 229 | - | expression tag |
His 230 | - | expression tag |
His 231 | - | expression tag |
His 232 | - | expression tag |
His 233 | - | expression tag |
His 234 | - | expression tag |
His 235 | - | expression tag |
Ser 236 | - | expression tag |
Ala 237 | - | expression tag |
Val 238 | - | expression tag |
Asp 239 | - | expression tag |
Glu 240 | - | expression tag |
Asn 241 | - | expression tag |
Leu 242 | - | expression tag |
Tyr 243 | - | expression tag |
Phe 244 | - | expression tag |
Gln 245 | - | expression tag |
Gly 246 | - | expression tag |
Gly 247 | - | expression tag |
Gly 248 | - | expression tag |
Arg 249 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -23 | - | initiating methionine |
Gly -22 | - | expression tag |
Ser -21 | - | expression tag |
Ser -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
Ser -13 | - | expression tag |
Ala -12 | - | expression tag |
Val -11 | - | expression tag |
Asp -10 | - | expression tag |
Glu -9 | - | expression tag |
Asn -8 | - | expression tag |
Leu -7 | - | expression tag |
Tyr -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 184534.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 490.8 | |
All* | Total formula weight | 185025.7 |